Registration Dossier
Registration Dossier
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EC number: 242-555-3 | CAS number: 18755-43-6
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No studies on toxicokinetics and metabolism of dimethyl propylphosphonate (DMPP) are available.
Dimethyl propylphosphonate (DMPP) is a homologous substance of dimethyl methylphosphonate (DMMP) and diethyl ethylphosphonate (DEEP) and a similar toxicokinetic profile pathway of metabolism can be assumed.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
No studies on toxicokinetics and metabolism of dimethyl propylphosphonate (DMPP) are available.
Dimethyl propylphosphonate (DMPP) is a homologous substance of dimethyl methylphosphonate (DMMP) and diethyl ethylphosphonate (DEEP) and a similar toxicokinetic profile pathway of metabolism can be assumed.
The biotransformation of DMMP and DEEP was studied in male and female rats after single oral doses of 50 and 100 mg/kg bw (Blumbach K, Paehler A, Deger HM, Dekant W, Biotransformation and male rat specific renal toxicity of diethyl ethyl- and dimethyl methylphosphonate, Toxicol. Sci 53, 24-32 (2000)).
[31]P and GC/MS showed that unchanged DMMP was excreted with urine; methylphosphonate was identified as the only metabolite in urine. Unchanged DEEP was also excreted with urine; in addition, ethyl ethylphosphonate and ethylphosphonate were urinary metabolites. The majority of the applied dose of both compounds was recovered in urine within 24 h indicating rapid absorption and excretion. No sex-differences in rats of formation or excretion of metabolites were seen.
Following this assumption DMPP is excreted in urine partly unchanged and additional as methyl propyl- and propylphosphonate. A rapid excretion is assumed as the majority of the lower homologues are recovered in urine within 24 hours.
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