Registration Dossier
Registration Dossier
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EC number: 700-102-1 | CAS number: 105112-76-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
A local lymph node assay performed with female CBA mice showed that 3,3'-[biphenyl-4,4'-diylbis(oxy)]dianiline does not possess skin sensitizing properties, so that no classification of the substance for this endpoint is required. No information has been reported about the potential of 3,3'-[biphenyl-4,4'-diylbis(oxy)]dianiline to induce respiratory sensitization. However, the inhalation route of exposure is considered as not relevant for the identified use of the substance.
Migrated from Short description of key information:
The skin sensitisation potential of 3,3'-[biphenyl-4,4'-diylbis(oxy)]dianiline using the murine local lymph node assay (LLNA) was assessed in compliance with OECD Guideline for Testing of Chemicals No. 429 "Skin Sensitisation: Local Lymph Node Assay" (Bull 2008b).
Respiratory sensitisation
Endpoint conclusion
- Additional information:
- Migrated from Short description of key information:
Not applicable.
Justification for classification or non-classification
Based on the sensitization rate which is below the threshold of significance (i.e. below 30%) set in Commission Directive 93/21/EEC (18th adaptation to technical progress of Council Directive 67/548/EEC), classification of 3,3'-[biphenyl-4,4'-diylbis(oxy)]dianiline as to its sensitising properties is not required.
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