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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards, well documented and acceptable for assessment.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Principles of method if other than guideline:
According to Federal Register 38, No. 187, § 1500.41, p. 27019 from 27 Sep. 1973
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(dimethylamino)ethyl acrylate
EC Number:
219-460-0
EC Name:
2-(dimethylamino)ethyl acrylate
Cas Number:
2439-35-2
Molecular formula:
C7H13NO2
IUPAC Name:
2-(dimethylamino)ethyl acrylate
Details on test material:
- Name of test material (as cited in study report): Dimethylaminoethylacrylat
- Purity: > 90 %

Test animals / tissue source

Species:
rabbit
Strain:
Vienna White
Details on test animals or tissues and environmental conditions:
- Source: Gaukler
- Weight at study initiation: mean 3.1 kg
- Diet: Ssniff

Test system

Vehicle:
unchanged (no vehicle)
Amount / concentration applied:
TEST MATERIAL
- Amount applied: 0.1 ml
- Concentration: undiluted
Duration of treatment / exposure:
unspecified
Observation period (in vivo):
8 days
Number of animals or in vitro replicates:
3

Results and discussion

Any other information on results incl. tables

A full scale scoring was not possilble due to suppuration in the eyes of all animals after administration of the test substance. The readings after 24, 48 and 72 hours are summarised as follows:

Animal No.

Reading time (h)

Corneal opacity

Iris lesion

Conjunctivae

Redness

Chemosis

1

24

1

0

2

4

48

*

*

2

4

72

*

*

*

4

mean

*

*

*

4

2

24

2

*

2

4

48

*

*

2

4

72

*

*

*

4

mean

*

*

*

4

3

24

2

*

2

4

48

2

1

2

3

72

*

*

*

4

mean

*

*

*

3.7

* Suppuration, scoring not possible.

The irritant/corrosive response data were not fully reversible within 8 days.

Applicant's summary and conclusion

Interpretation of results:
highly irritating
Remarks:
Migrated information
Conclusions:
Classification: risk of serious damage to eyes