Registration Dossier
Registration Dossier
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EC number: 201-224-3 | CAS number: 79-77-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Data from secondary source which meets basic scientific principles. Due to structural similarities of the registered substance trans-ß-ionone (CAS 79-77-6) and the used test substance ß-ionone (CAS 14901-07-6) the study data could be taken into account for assessment.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Short term toxicity study on alpha-ionone, beta-ionone and citral
- Author:
- Givaudan
- Year:
- 1 980
- Bibliographic source:
- cited in the RIFM/FEMA database, location 43485
- Report date:
- 1980
- Reference Type:
- secondary source
- Title:
- Fragrance material review on alpha-ionone
- Author:
- Lalko J et al.
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology 45 (2007) S235–S240
- Reference Type:
- secondary source
- Title:
- A toxicologic and dermatologic assessment of ionones when used as fragrance ingredients
- Author:
- Belsito D et al.
- Year:
- 2 007
- Bibliographic source:
- Food and Chemical Toxicology 45 (2007) S130–S167
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Administration: daily, 5 times
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 4-(2,6,6-trimethylcyclohex-1-ene-1-yl)-but-3-ene-2-one
- EC Number:
- 238-969-9
- EC Name:
- 4-(2,6,6-trimethylcyclohex-1-ene-1-yl)-but-3-ene-2-one
- Cas Number:
- 14901-07-6
- IUPAC Name:
- 4-(2,6,6-trimethylcyclohex-1-en-1-yl)but-3-en-2-one
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- - Administration: daily, 5 times
- Doses:
- no data
- No. of animals per sex per dose:
- 10 animals/dose
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 7 120 mg/kg bw
- Remarks on result:
- other: +/- 1000 mg/kg bw for deaths occuring within 24 h
- Sex:
- not specified
- Dose descriptor:
- other: LD10
- Effect level:
- 4 120 mg/kg bw
- Remarks on result:
- other: for deaths occuring within 24 h
- Sex:
- not specified
- Dose descriptor:
- other: LD90
- Effect level:
- 12 300 mg/kg bw
- Remarks on result:
- other: for deaths occuring within 24 h
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 290 mg/kg bw
- Remarks on result:
- other: +/- 500 mg/kg bw for deaths occuring within 10 days
- Sex:
- not specified
- Dose descriptor:
- other: LD10
- Effect level:
- 2 150 mg/kg bw
- Remarks on result:
- other: for deaths occuring within 10 days
- Sex:
- not specified
- Dose descriptor:
- other: LD90
- Effect level:
- 5 040 mg/kg bw
- Remarks on result:
- other: for deaths occuring within 10 days
- Mortality:
- All deaths had occurred by 24 hours
Applicant's summary and conclusion
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