Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
not specified
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Information from handbook, no study details were provided.

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Registry of Toxic Effects of Chemical Substances 1981 - 82, Volume 2, D-O
Author:
U.S. Department of Health and Human Services
Year:
1981
Bibliographic source:
NIOSH National Institute for Occupational Safety and Health
Reference Type:
other: internet data base
Title:
GESTIS Substance database
Author:
German Social Accident Insurance
Year:
2012
Bibliographic source:
http://www.dguv.de/ifa/en/gestis/stoffdb/index.jsp
Reference Type:
review article or handbook
Title:
Bis(2-chloroethyl)ether, BUA Report 21 (December 1987)
Author:
BUA
Year:
1987
Bibliographic source:
Beratergremium für Umweltrelevante Altstoffe (BUA)ISBN 3-527-28515-6 (VCH, Weinheim)

Materials and methods

Principles of method if other than guideline:
no information provided
GLP compliance:
not specified
Test type:
other: no information provided

Test material

Constituent 1
Chemical structure
Reference substance name:
Bis(2-chloroethyl) ether
EC Number:
203-870-1
EC Name:
Bis(2-chloroethyl) ether
Cas Number:
111-44-4
Molecular formula:
C4H8Cl2O
IUPAC Name:
1-chloro-2-(2-chloroethoxy)ethane

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: unspecified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
75 mg/kg bw

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category III
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
oral rat LD50: 75 mg/kg bw
Executive summary:

The handbook and database provide an oral rat LD50 of 75 mg/kg bw. No further information was provided. Based on the limited information, the relevance and validity of the data cannot be assessed.

Reference was made to the following publication:

Journal of Industrial Hygiene and Toxicology. Vol. 30, Pg. 63, 1948.