Registration Dossier
Registration Dossier
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EC number: 203-870-1 | CAS number: 111-44-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- not specified
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Information from handbook, no study details were provided.
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Registry of Toxic Effects of Chemical Substances 1981 - 82, Volume 2, D-O
- Author:
- U.S. Department of Health and Human Services
- Year:
- 1 981
- Bibliographic source:
- NIOSH National Institute for Occupational Safety and Health
- Reference Type:
- other: internet data base
- Title:
- GESTIS Substance database
- Author:
- German Social Accident Insurance
- Year:
- 2 012
- Bibliographic source:
- http://www.dguv.de/ifa/en/gestis/stoffdb/index.jsp
- Reference Type:
- review article or handbook
- Title:
- Bis(2-chloroethyl)ether, BUA Report 21 (December 1987)
- Author:
- BUA
- Year:
- 1 987
- Bibliographic source:
- Beratergremium für Umweltrelevante Altstoffe (BUA)ISBN 3-527-28515-6 (VCH, Weinheim)
Materials and methods
- Principles of method if other than guideline:
- no information provided
- GLP compliance:
- not specified
- Test type:
- other: no information provided
Test material
- Reference substance name:
- Bis(2-chloroethyl) ether
- EC Number:
- 203-870-1
- EC Name:
- Bis(2-chloroethyl) ether
- Cas Number:
- 111-44-4
- Molecular formula:
- C4H8Cl2O
- IUPAC Name:
- 1-chloro-2-(2-chloroethoxy)ethane
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: unspecified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 75 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- oral rat LD50: 75 mg/kg bw
- Executive summary:
The handbook and database provide an oral rat LD50 of 75 mg/kg bw. No further information was provided. Based on the limited information, the relevance and validity of the data cannot be assessed.
Reference was made to the following publication:
Journal of Industrial Hygiene and Toxicology. Vol. 30, Pg. 63, 1948.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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