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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
sub-chronic toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: information from assessment report

Data source

Reference
Reference Type:
review article or handbook
Title:
Bis(2-chloroethyl)ether, BUA Report 21 (December 1987)
Author:
BUA
Year:
1987
Bibliographic source:
Beratergremium für Umweltrelevante Altstoffe (BUA)ISBN 3-527-28515-6 (VCH, Weinheim)

Materials and methods

Principles of method if other than guideline:
no information
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Bis(2-chloroethyl) ether
EC Number:
203-870-1
EC Name:
Bis(2-chloroethyl) ether
Cas Number:
111-44-4
Molecular formula:
C4H8Cl2O
IUPAC Name:
1-chloro-2-(2-chloroethoxy)ethane

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
7 hours daily 5 days per week

Results and discussion

Results of examinations

Body weight and weight changes:
effects observed, treatment-related
Description (incidence and severity):
420 mg/m3 in male rats

Effect levels

Dose descriptor:
LOAEL
Effect level:
420 mg/m³ air
Based on:
not specified
Sex:
male
Basis for effect level:
body weight and weight gain

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

The BUA assessment report has following statement:

"Within a period of 130 days, an air concentration of 420 mg/m³, inhaled by rats and guinea pigs 7 hours daily, 5 days per week, led to delayed weight gain of the male animals as opposed to the untreated control animals."

Applicant's summary and conclusion

Executive summary:

The BUA assessment report has following statement:

"Within a period of 130 days, an air concentration of 420 mg/m³, inhaled by rats and guinea pigs 7 hours daily, 5 days per week, led to delayed weight gain of the male animals as opposed to the untreated control animals."