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EC number: 273-521-6 | CAS number: 68988-22-7 A complex residuum from the distillation of products from the manufacture of dimethyl terephthalate by air oxidation and esterification of p-xylene. It consists of polyphenyl polyesters.
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Toxicity of the submission substance towards algae had been determined in a toxicity test on the freshwater alga Pseudokirchnerella subcapitata according to OECD 201.
EC50 (growth rate) >100 mg/L (nominal concentraion)
Key value for chemical safety assessment
Additional information
The submission substance was tested for toxicity to fresh water alga Pseudokirchnerella subcapitata according to OECD 201 and EU-meothod C.3 (GLP-compliance).
As the test item was not fully soluble in water, measured concentrations are deviating significiantly from the nominal concentrations. As shown by measured TOC values test substance concentrations increased with increasing loading rates and were stable throughout the test. From this it can be concluded that only a small fraction (the "more water soluble fraction") of this UVCB substance is solved in water and that its concentration in water is depending on the total amount of substance provided to the water phase. As it is reasonable to assume that this solved fraction is available to aquatic organisms and is responsible for the aquatic toxicity observed, the nominal concentrations (loading rate) are used to characterise the observed toxicity. Measured concentrations were stable throughout the test. Exponential growth was observed for the control samples.
Statistically significant reduction of growth rate was found at loading rates of 10 mg/l and higher (Bonferroni t and Tukey test, a = 0.05). Statistically significant inhibition of yield was found at all loading rates (Bonferroni t and Tukey test, a = 0.05).
The following effect concentration had been determined:
1) Growth rate reduction:
NOEC = 0.66 mg/L (3.2 mg/L nominal concentration)
EC10 = 1.8 mg/L (3.2 - 10 mg/L nominal concentration)
EC50 >8.3 mg/L (>100 mg/L nominal concentraion)
2) Reduction of yield:
NOEC < 0.2 mg/L (<1 mg/L nominal concentration)
EC10 = 0.66 mg/L (3.2 mg/L nominal concentration)
EC50 = 3.4 mg/L (10 -32 mg/L nominal concentration)
Other than yield the average specific growth rate is independent from the specific growth rate of the algal species or algal strain used or the experimental conditions and therefore preferred over yield reduction.
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