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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

basic toxicokinetics in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Information retrieved from secondary source (OECD SIDS report)

Data source

Reference Type:
review article or handbook
Dimethyl terephthalate, CAS N°: 120-61-6 -SIDS Initial Assessment Report For SIAM 11 - United States, January 23-26, 2001
United States/IT National SIDS Contact Point in Sponsor Country: Oscar Hernandez Director, Risk Assessment Division Office of Pollution Prevention and Toxics US EPA Washington, DC 20460
Bibliographic source:
OECD - UNEP Chemicals 11-13 chemin des Anémones, CH-1219 Châtelaine Geneva, Switzerland

Materials and methods

Objective of study:
Principles of method if other than guideline:
combined toxicokinetic information from several in vivo toxicokinetic studies
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Dimethyl terephthalate
EC Number:
EC Name:
Dimethyl terephthalate
Cas Number:
Molecular formula:
dimethyl terephthalate
Details on test material:
Dimetthyl terephthalate

Administration / exposure

Route of administration:
oral: unspecified

Results and discussion

Toxicokinetic / pharmacokinetic studies

Details on absorption:
Several studies conducted in rats, rabbits, and mice are summarised in the OECD SIDS document. These studies show that dimethyl terephthalate is readily absorbed from the gastrointestinal tract.
Details on excretion:
In the studies summarised in the OECD SIDS document the test substance was rapidly eliminated in the urine within 48-hours

Metabolite characterisation studies

Details on metabolites:
Absorbed dimethyl terephthalate was metabolized to terephthalic acid (TPA) via hydrolysis (partly precipitated as TPA-Ca++). In mice, monomethyl terephthalate was the major metabolite.

Applicant's summary and conclusion

Executive summary:

Information from a peer-reviewed secondary source (OECD SIDS) shows that the major component of the submission substance, dimethyl terephthalate is well absorbed from the gastrointestinal tract, metabolised by hydrolysis to terephthalic acid (in mice: monomethyl terephthalate), and mainly excreted in the urine.