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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Classification & Labelling & PBT assessment

PBT assessment

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Administrative data

PBT assessment: overall result

PBT status:
the substance is not PBT / vPvB

Based on the assessment the substance is not considered as PBT / vPvB.

The substance degraded approximately 4% in 28 days in the Closed Bottle test (OECD 301D). Phenol, 2,4,6-tris[(dimethylamino) methyl]- is therefore not readily biodegradable.

The substance has a high solubility and will remain dissolved in water, not partitioning to sediment. The substance is susceptible to rapid photolysis, and this may be the key removal mechanism.

The substance has a very high solubility and a low lipophilic potential and is thus very unlikely to bioaccumulate. The logKow value of -0.66 is clearly below the trigger value for bioaccumulation.


The substance is practically non-toxic to invertebrates and fish, however algal growth was inhibited, with an EC50 (72 hours) of 46.7 mg/L and a NOEC of 6.44mg/L.

Substance is not classified as carcinogenic, mutagenic or toxic for reproduction and no other evidence of chronic toxicity of relevance was identified.

Based on modelled data (Catalogic v.5.13.1_CATALOGIC 301C v.11.15.) relevant degradation products do neither fulfil the PBT criteria (not PBT) nor the vPvB criteria (not vPvB)