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Environmental fate & pathways

Biodegradation in water: screening tests

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Description of key information

The ready biodegradability was evaluated by Safepharm Laboratories (1996) in a Closed Bottle Test according to OECD 301D.

The test material was exposed to sewage treatment microorganisms at a concentration of 2 mg/l at 21 C for 28 days. The test material was not toxic to the inoculum. The test material attained 4 % degradation after 28 days.

This finding is supported by a calculation of ready biodegradation in water using CATALOGIC v.5.13.1. estimating a Biological Oxygen Demand (BOD) according to OECD 301C. The estimated BOD is 32% within 28 days. Therefore, the substance cannot be considered to be readily biodegradable.


Key value for chemical safety assessment

Biodegradation in water:
not biodegradable
Type of water:

Additional information

Sufficient data are available to assess the PBT/vPvB properties of 2,4,6-tris(dimethylaminomethyl)phenol.

Potential relevant degradation products were modelled using (Q)SAR model CATALOGIC 301C v11.15 – July 2018 (OASIS CATALOGIC v5.13.1.156):

Based on modelled data relevant degradation products present in concentration of ≥ 0.1% (~ equivalent to quantity setting in OASIS CATALOGIC: 0.001-2 [mol/mol parent]) do neither fulfil the PBT criteria (not PBT) nor the vPvB criteria (not vPvB).

Without exception, all the 62 modelled degradation products of 2,4,6‐tris(dimethylaminomethyl) phenol were estimated to exhibit log Kow values of clearly ≤4.5 (see Table 1 of endpoint entry), thereby not fulfilling the screening criteria for bioaccumulation (B/vB) as laid down in Section 3.1 of REACH Annex XIII.

However, 12 predicted relevant metabolites present in concentration of ≥0.1% (~ equivalent to quantity setting in OASIS CATALOGIC: 0.001-2 [mol/mol parent]) should be considered as potentially P/vP from a precautionary point of view.