α,α,α-trifluoro-m-toluidine

Melting point / freezing point

Administrative data

Endpoint:

melting point/freezing point

Type of information:

experimental study

Adequacy of study:

key study

Study period:

09 November 2010 to 24 November 2010

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Remarks:

This study was conducted in accordance with Method A1 "Melting/Freezing Temperature" of Commission Regulation (EC) No 440/2008 of 30 May 2008. This study was performed in compliance with UK GLP standards (Schedule 1, Good Laboratory Practice Regulations 1999 (SI 1999/3106 as amended by SI 2004/0994).

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2011

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method A.1 (Melting / Freezing Temperature)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

other: BS4633

Test material

Test material information

Constituent 1

Reference substance name:

3-trifluoromethylaniline

IUPAC Name:

3-trifluoromethylaniline

Details on test material:

Identification: 3-trifluoromethylaniline
Description: Extremely pale yellow liquid
Purity: 99.66 %
Batch Number: 101009
Date Received: 25 October 2010
Storage Conditions: Room temperature in the dark

Results and discussion

Melting / freezing point

Melting / freezing pt.:

<= -4.5 °C

Any other information on results incl. tables

The results for the freezing temperature determinations indicated much super-cooling of the test item prior to solidifying. This effect was confirmed using differential scanning calorimetry (DSC), whereupon the test item did not freeze until the calorimeter had reached a temperature of -30 degrees celsius (243 kelvin), and then, upon warming, the test item melted at -13.4 degrees celsius (259.8 kelvin). The DSC thermogram is presented in the study report.

Due to the associated problems of super-cooling of the test item, a third freezing temperature determination was subsequently carried out, using crushed glass and a lower cooling rate in an attempt to aid the seeding process. However, the results again indicated much super-cooling of the test item, and a freezing temperature of -12 degrees celsius (261 kelvin).

Applicant's summary and conclusion

Conclusions:

The freezing temperature has been determined to be less than or equal to 4.5 +/- 0.5 degrees celsius (278 +/- 0.5 kelvin). However, the results also indicated much super-cooling of the test item.