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EC number: 202-643-4 | CAS number: 98-16-8
Melting point / freezing point
Administrative data
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 November 2010 to 24 November 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- This study was conducted in accordance with Method A1 "Melting/Freezing Temperature" of Commission Regulation (EC) No 440/2008 of 30 May 2008. This study was performed in compliance with UK GLP standards (Schedule 1, Good Laboratory Practice Regulations 1999 (SI 1999/3106 as amended by SI 2004/0994).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- other: BS4633
Test material
- Reference substance name:
- 3-trifluoromethylaniline
- IUPAC Name:
- 3-trifluoromethylaniline
- Details on test material:
- Identification: 3-trifluoromethylaniline
Description: Extremely pale yellow liquid
Purity: 99.66 %
Batch Number: 101009
Date Received: 25 October 2010
Storage Conditions: Room temperature in the dark
Constituent 1
Results and discussion
Melting / freezing point
- Melting / freezing pt.:
- <= -4.5 °C
Any other information on results incl. tables
The results for the freezing temperature determinations indicated much super-cooling of the test item prior to solidifying. This effect was confirmed using differential scanning calorimetry (DSC), whereupon the test item did not freeze until the calorimeter had reached a temperature of -30 degrees celsius (243 kelvin), and then, upon warming, the test item melted at -13.4 degrees celsius (259.8 kelvin). The DSC thermogram is presented in the study report.
Due to the associated problems of super-cooling of the test item, a third freezing temperature determination was subsequently carried out, using crushed glass and a lower cooling rate in an attempt to aid the seeding process. However, the results again indicated much super-cooling of the test item, and a freezing temperature of -12 degrees celsius (261 kelvin).
Applicant's summary and conclusion
- Conclusions:
- The freezing temperature has been determined to be less than or equal to 4.5 +/- 0.5 degrees celsius (278 +/- 0.5 kelvin). However, the results also indicated much super-cooling of the test item.
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