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Diss Factsheets

Environmental fate & pathways

Adsorption / desorption

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Administrative data

Link to relevant study record(s)

Description of key information

Adsorption to the solid soil phase is not expected.

Key value for chemical safety assessment

Additional information

QSAR-disclaimer

In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. Furthermore according to Article 25 of the same Regulation testing on vertebrate animals shall be undertaken only as a last resort.

According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.

For the assessment of MIPA (Q)SAR results were used for the estimation of the adsorption potential. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.

 

Therefore, further experimental studies on the adsorption potential are not provided.

According to Regulation (EC) No 1907/2006, Annex VIII, Section 9.3.1, Column 2, the study on adsorption/desorption screening does not need to be conducted if based on the physicochemical properties the substance can be expected to have a low potential for adsorption (e.g. the substance has a low octanol water partition coefficient). MIPA has a measured log Kow of -0.93 (23 °C; BASF AG,1987; see IUCLID Ch. 4.7).

According to Regulation (EC) No 1907/2006, Annex VIII, Section 9.3.1, Column 2, the study on adsorption/desorption screening does not need to be conducted if based on the physicochemical properties the substance and its relevant degradation products decompose rapidly. MIPA is readily biodegradable (DOW Chemical, 1998; see IUCLID Ch. 5.2.1).

 

Assessment

At environmentally relevant conditions, MIPA will be present in ionised form (pKa = 9.62; Perrin, 1972). Therefore, the adsorption coefficient was calculated according to Franco & Trapp (2008, 2009, 2010) to correct for the charged molecule at pH 5, 7, and 8. This pH range is representative for 98% of the European soils. The method is based on the dissociation constant pKa and the log Kow for the uncharged moelcule. The resulting Koc at pH 5 to pH 7 is 34.0 L/kg and 33 L/kg at pH 8. The log Koc at pH 5 to 7 is 1.53 and 1.52 at pH 8 (BASF SE, 2021). The substance is within the applicability domain of the model.

 

It can be concluded that adsorption to the solid soil phase is not to be expected.