Registration Dossier

Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

Acutely harmful to aquatic algae and cyanobacteria. 

Key value for chemical safety assessment

EC50 for freshwater algae:
32.7 mg/L
EC50 for marine water algae:
39 mg/L
EC10 or NOEC for freshwater algae:
15.1 mg/L

Additional information

The acute toxicity of MIPA (CAS 78-96-6) to aquatic algae and cyanobacteria was investigated in a test conducted according to DIN 38412, part 9, using Desmodesmus subspicatus as test organism (BASF AG, 1989). Based on growth rate, the 72-h ErC50 was determined to be 32.7 mg/L (72-h ErC10 = 15.1 mg/L) indicating the test substance to be acutely harmful to algae. The test substance solutions were not neutralized.


The study was conducted without analytical monitoring. However, the stability of MIPA in the test medium is considered to be stable due to the high water solubility (miscible at any ratio; see IUCLID chapter 4.8), the low vapour pressure (63 Pa at 25 °C; see IUCLID chapter 4.6) and the low Henry's law constant (HLC: 4.95E-5 Pa*m3/mol; calculated; HENRYWIN v3.20, EPISuite v4.11) of the substance.


In addition, Eide-Haugmo et al. (2012/2009) performed a guideline study according to ISO 10253 with the marine algae Skeletonema costatum. After 72 hours an ErC50 of 39.0 mg/L was determined.