Registration Dossier
Registration Dossier
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EC number: 204-633-5 | CAS number: 123-51-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Study period:
- 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- inhalation hazard test; 8-hour exposure period
- Justification for type of information:
- A read-across justification is provided in the IUCLID Chapter "Assessment reports"
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Principles of method if other than guideline:
- Rats were exposed to a saturated solution for 8 hours and observed for 14 days.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Pentan-1-ol
- EC Number:
- 200-752-1
- EC Name:
- Pentan-1-ol
- Cas Number:
- 71-41-0
- Molecular formula:
- C5H12O
- IUPAC Name:
- pentan-1-ol
- Details on test material:
- No additional information available.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- Concentrations:
- rats were exposed to an essentially saturated solution.
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- other: Inhalation hazard test
- Exp. duration:
- 8 h
- Remarks on result:
- other: No mortality occurred and no clinical signs were observed when rats were exposed for 8 hours to a saturated atmosphere of test substance vapours.
- Mortality:
- No mortality was observed in rats exposed to a substantially saturated vapor for 8 hours.
- Clinical signs:
- other: There were no clinical signs observed during the exposure period or observation period.
- Body weight:
- Exposed animals gained 53 to 82 g during the observation period.
- Gross pathology:
- There were no gross pathologic effects noted at the end of the observation period.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- No hazard is anticipated from the infrequent inhalation of substantially saturated vapor generated at room temprature under handlimg conditions.
- Executive summary:
A group of 6 rats were exposed to an essentially saturated atmosphere of n-propanol for 8 hours. No significant effects were noted during or following exposure to an essentially saturated atmosphere of n-pentanol.
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