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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Administrative data

Link to relevant study record(s)

Description of key information

Parent compound pivaloyl chloride (CAS 3282-30-2): No data available

Hydrolysis product pivalic acid (CAS 75-98-9): with high probability acutely not harmful to aquatic invertebrates.

Hydrolysis product HCl (CAS 7647-01-0): Acutely very toxic for aquatic invertebrates (pH dependent).


Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Dose descriptor:
Pivalic acid
Effect concentration:
202.9 mg/L

Additional information

No data for the parent compound pivaloyl chloride (CAS 3282-30-2) are available. However, the parent compound rapidly hydrolyses in contact with water and forms pivalic acid (CAS 75-98-9) and HCl (CAS 7647-01-0). Therefore, the acute toxicity to aquatic invertebrates will be assessed based on the information available for the hydrolysis products pivalic acid and HCl.


Parent compound pivaloyl chloride:

No data available.


Hydrolysis product pivalic acid:

The acute toxicity of the hydrolysis product pivalic acid to aquatic invertebrates was tested according to US EPA – 660/3-75-009 (Methods for Acute Toxicity with fish and Macroinvertebrates, and Amphibians; 1975) using Daphnia magna as test organism (EG & G Bionomics, 1977). The 48-h EC50 was found to be 202.9 mg/L, based on nominal test concentrations.


Hydrolysis product HCL:

HCl was tested in an acute toxicity test according to OECD 202 with D. magna. The 48-h EC50 was 0.492 mg/L (acid equivalent to pH 5.3; MITI, 1999; peer reviewed data: OECD SIDS, 2002).