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EC number: 292-637-8
CAS number: 90641-13-7
A complex combination of hydrocarbons produced by the distillation of the products from a steam cracking process thereafter treated with hydrogen in the presence of a catalyst. It consists predominantly of aromatic hydrocarbons having carbon numbers in the range of C9 through C10 and boiling in the range of approximately 140°C to 200°C (284°F to 392°F).
test animal died following the 3rdinduction. No visible
lesions were seen when examined post mortem.
grades, severity and incidence following challenge with a 1:4 v/v
dilution of E000144700 did not produce a higher response than that
observed for the negative control group.
vehicle control group animals were free of dermal lesions throughout the
sensitization potential of E00014470 (CAS 68516-20-1) was investigated
in male guinea pigs dermally exposed to a 1:2 v/v dilution of 0.5 mL
E000144700 in mineral oil for each of 3 induction phases. Following
challenge with a 1:4 dilution response grades, severity and incidence
were not greater than those at the control group site. The positive
control, DNCB, produced significantly higher responses than in the
control group which were free of dermal lesions throughout the study
is concluded that E000144700 (CAS 68516-20-1) is not a skin sensitiser
and no classification is warranted under GHS/CLP.
68516-20-1 (E000144700) was not a sensitiser in albino guinea pigs
dermally exposed to a 1:2 dilution of E000144700 at a volume of 0.5 mL
for 3 induction phases and to a 1:4 v/v dilution (in mineral oil) for
the challenge (UBTL, 1990e). The
data available on marker constituents: benzene, toluene, cyclohexane,
and xylene indicate that they are not skin sensitisers.
data identified was for benzene and xylene
(Kligman, 1966). The details of the study are not further discussed in
the dossier due to ethical reasons.
AM (1966). The identification of contact allergens by human assay. III
The maximization test: a procedure for screening and rating contact
sensitizers. J Int Dermatol, 47 (5), 393-409.
Migrated from Short description of key information:
High Benzene Naphtha streams are considered not to be skin or
respiratory sensitisers. The marker constituents: benzene, toluene,
cyclohexane, and xylene are considered not to be skin sensitisers.
Justification for selection of skin sensitisation endpoint:
Information available for representative streams and the marker
constituents present indicate no potential to induce or elicit skin
specific animal or human data have been found with regard to respiratory
sensitisation for any components within this stream.
No data have been found concerning respiratory sensitisation and there
are no indications that components within this stream are respiratory
are sufficient data on CAS 68516-20-1 and on marker constituents to
indicate that High Benzene Naphtha streams are not skin or respiratory
sensitisers and no classification is warranted for these endpoints under
Reg (EC) 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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