Registration Dossier

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Abstract information in OECD SIDS report of 2004; study described in OECD SIDS as valid with restrictions because of poor documentation and low number of animals.

Data source

Reference
Reference Type:
secondary source
Title:
SIDS Initial Assessment Report For SIAM 19 - 3-Hydroxy-2-naphthoic acid
Author:
Anonymous
Year:
2004
Bibliographic source:
UNEP Publications

Materials and methods

Principles of method if other than guideline:
1 animal/dose level. Occlusive treatment (rubber cuff and gum pads). 24 hours exposure.
GLP compliance:
no
Test type:
other: no data
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
3-hydroxy-2-naphthoic acid
EC Number:
202-180-8
EC Name:
3-hydroxy-2-naphthoic acid
Cas Number:
92-70-6
Molecular formula:
C11H8O3
IUPAC Name:
3-hydroxy-2-naphthoic acid

Test animals

Species:
guinea pig

Administration / exposure

Type of coverage:
occlusive
Duration of exposure:
24h
Doses:
5; 10; 20 cc/kg (appr. 500; 1000; 2000 mg/kg bw) as a 10 % solution in vehicle
No. of animals per sex per dose:
1

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 1 000 - < 2 000 mg/kg bw

Applicant's summary and conclusion