Registration Dossier

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Abstract information in OECD SIDS report of 2004; study described in OECD SIDS as valid without restrictions.

Data source

Reference
Reference Type:
secondary source
Title:
SIDS Initial Assessment Report For SIAM 19 - 3-Hydroxy-2-naphthoic acid
Author:
Anonymous
Year:
2004
Bibliographic source:
UNEP Publications

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
not specified
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3-hydroxy-2-naphthoic acid
EC Number:
202-180-8
EC Name:
3-hydroxy-2-naphthoic acid
Cas Number:
92-70-6
Molecular formula:
C11H8O3
IUPAC Name:
3-hydroxy-2-naphthoic acid

Test animals / tissue source

Species:
rabbit

Test system

Vehicle:
other: polyethylene glycol 400
Controls:
not required
Amount / concentration applied:
100 mg
Duration of treatment / exposure:
single
Observation period (in vivo):
Eyes were examined after 1, 24, 48, 72 hours and on day 7 and 14 after application.
Number of animals or in vitro replicates:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
other: 24-72h
Score:
1.1
Reversibility:
other:
Remarks on result:
other: corneal vascularization was observed in all animals 7 days after the application
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
other: 24-72h
Score:
1.9
Reversibility:
fully reversible
Irritation parameter:
chemosis score
Basis:
mean
Time point:
other: 24-72h
Score:
1.3
Reversibility:
fully reversible
Other effects:
At 24, 48 and 72 hours, conjunctivitis and diffuse corneal opacities were found.
7 days after the application, corneal vascularization was observed in all animals.

Any other information on results incl. tables

1 hour after application, swelling and conjunctival injection as well as secretion (clear, tinted by the test substance) were observed in all animals. One animal showed iritis at 24 and 48 hours.

Applicant's summary and conclusion

Interpretation of results:
highly irritating
Remarks:
Migrated information