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Physical & Chemical properties

Surface tension

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Administrative data

Endpoint:
surface tension
Type of information:
experimental study
Adequacy of study:
key study
Study period:
October 1996 and 9 January 1997
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study conducted according to method A5 as described in the EEC Methods for the determination of physicochemical properties, Directive 92/69/EEC and in accordance with cGLP .

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1997
Report date:
1997

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
EU Method A.5 (Surface Tension)
Deviations:
no
Principles of method if other than guideline:
The test vessel was half-filled with liquid, put on the tensiometer test platform, and raised so that the ring was 2 - 3 mm below the liquid surface. The platform was lowered to draw a lamella from the liquid surface. The maximum force which arose just before the lamella was torn off is the surface tension and was recorded by the chart recorder. Measurements were made at 2 minute intervals until a constant value (to within 0.1 mN/m) were recorded. The room temperature was monitored throughout the test.
The following order of tests were performed using the above method: distilled water, test solution 1, test solution 2 and distilled water.
GLP compliance:
yes
Type of method:
OECD harmonised ring method

Test material

Constituent 1
Chemical structure
Reference substance name:
2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)benzoic acid
EC Number:
424-110-7
EC Name:
2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)benzoic acid
Cas Number:
194602-23-8
Molecular formula:
C14 H20 N2 O5 S
IUPAC Name:
2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]benzoic acid
Test material form:
solid: crystalline
Details on test material:
Date recieved: 2 October 1996
intended use: Pharma intermediate

Results and discussion

Surface tension
Surface tension:
71.8 mN/m
Temp.:
16.5 °C
Conc.:
1 g/L

Applicant's summary and conclusion

Conclusions:
The surface tension of a lg/I aqueous solution ofUK-143,108 is 71.8 mN/m at 16.5°C.

Under the terms of the EEC Directive UK-143, 108 is not considered to be a surface active material at 16.5°C because the surface tension is greater than 60 mN/m.