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EC number: 232-752-2 | CAS number: 9014-01-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Identification
- Display Name:
- Subtilisin
- EC Number:
- 232-752-2
- EC Name:
- Subtilisin
- CAS Number:
- 9014-01-1
- Molecular formula:
- Not available.
- IUPAC Name:
- Subtilisin
Type of substance
- Composition:
- UVCB
- Origin:
- other: Enzyme
Total tonnage band
- Total range:
- 1 000 - 10 000 tonnes per annum
REACH
- Registered as:
- FULL
- Submitted:
- Joint Submission
Publication dates
- First published:
- 16-Mar-2011
- Last modified:
- 01-Sep-2020
Chemical safety assessment
- Performed for this substance:
- YES
Compositions open all close all
- Type:
- legal entity composition of the substance
- State Form:
- solid: bulk
Constituent 1
- Reference substance name:
- Active enzyme protein of Subtilisin (EC no. 232-752-2, CAS no. 9014-01-1, EC name: Subtilisin, Enzyme Class No.: 3.4.21.62)
- Molecular formula:
- Not avaiable
- IUPAC Name:
- Active enzyme protein of Subtilisin (EC no. 232-752-2, CAS no. 9014-01-1, EC name: Subtilisin, Enzyme Class No.: 3.4.21.62)
Constituent 2
- Reference substance name:
- Protein as a constituent of enzyme deriving from the fermentation or extraction process
- Molecular formula:
- Not available
- IUPAC Name:
- Protein as a constituent of enzyme deriving from the fermentation or extraction process
Constituent 3
- Reference substance name:
- Carbohydrates constituent of enzyme deriving from the fermentation or extraction process
- Molecular formula:
- Not available.
- IUPAC Name:
- Carbohydrates constituent of enzyme deriving from the fermentation or extraction process
Constituent 4
- Reference substance name:
- Lipids as a constituent of enzyme deriving from the fermentation or extraction process
- Molecular formula:
- Not available.
- IUPAC Name:
- Lipids as a constituent of enzyme deriving from the fermentation or extraction process
Constituent 5
- Reference substance name:
- Inorganic salts as a constituent of enzyme deriving from the fermentation or extraction process
- Molecular formula:
- Not available.
- IUPAC Name:
- Inorganic salts as a constituent of enzyme deriving from the fermentation or extraction process
- Type:
- legal entity composition of the substance
- State Form:
- solid: bulk
Constituent 1
- Reference substance name:
- Active enzyme protein of Subtilisin (EC no. 232-752-2, CAS no. 9014-01-1, EC name: Subtilisin, Enzyme Class no. 3.4.21.62)
- IUPAC Name:
- Active enzyme protein of Subtilisin (EC no. 232-752-2, CAS no. 9014-01-1, EC name: Subtilisin, Enzyme Class no. 3.4.21.62)
Constituent 2
- Reference substance name:
- Protein as a constituent of enzyme deriving from the fermentation or extraction process
- Molecular formula:
- Not available. See remarks.
- IUPAC Name:
- Protein as a constituent of enzyme deriving from the fermentation or extraction process
Constituent 3
- Reference substance name:
- Carbohydrates as a constituent of enzyme deriving from the fermentation or extraction process
- Molecular formula:
- Not available. See remarks.
- IUPAC Name:
- Carbohydrates as a constituent of enzyme deriving from the fermentation or extraction process
Constituent 4
- Reference substance name:
- Lipids as a constituent of enzyme deriving from the fermentation or extraction process
- Molecular formula:
- Not available. See remarks.
- IUPAC Name:
- Lipids as a constituent of enzyme deriving from the fermentation or extraction process
Constituent 5
- Reference substance name:
- Inorganic salts as a constituent of enzyme deriving from the fermentation or extraction process
- Molecular formula:
- Not available. See remarks.
- IUPAC Name:
- Inorganic salts as a constituent of enzyme deriving from the fermentation or extraction process
- Type:
- legal entity composition of the substance
- State Form:
- solid: bulk
Constituent 1
- Reference substance name:
- Subtilisin
- EC Number:
- 232-752-2
- EC Name:
- Subtilisin
- CAS Number:
- 9014-01-1
- Molecular formula:
- Not available.
- IUPAC Name:
- Subtilisin
Constituent 2
- Reference substance name:
- amino acids
- IUPAC Name:
- amino acids
Constituent 3
- Reference substance name:
- Carbohydrates
- IUPAC Name:
- Carbohydrates
Constituent 4
- Reference substance name:
- Extractable lipids
- IUPAC Name:
- Extractable lipids
Constituent 5
- Reference substance name:
- Dipotassium phosphonate
- EC Number:
- 236-809-2
- EC Name:
- Dipotassium phosphonate
- CAS Number:
- 13492-26-7
- Molecular formula:
- H3O3P.2K
- IUPAC Name:
- Dipotassium phosphonate
Constituent 6
- Reference substance name:
- Sodium sulphate
- EC Number:
- 231-820-9
- EC Name:
- Sodium sulphate
- CAS Number:
- 7757-82-6
- Molecular formula:
- H2O4S.2Na
- IUPAC Name:
- Sodium sulphate
Constituent 7
- Reference substance name:
- Sodium chloride
- EC Number:
- 231-598-3
- EC Name:
- Sodium chloride
- CAS Number:
- 7647-14-5
- Molecular formula:
- ClNa
- IUPAC Name:
- sodium chloride
- Type:
- legal entity composition of the substance
Constituent 1
- Reference substance name:
- Total proteins including enzymes
- IUPAC Name:
- Total proteins including enzymes
Constituent 2
- Reference substance name:
- Carbohydrates
- IUPAC Name:
- Carbohydrates
Constituent 3
- Reference substance name:
- Lipids
- IUPAC Name:
- Lipids
Constituent 4
- Reference substance name:
- Inorganic salts
- IUPAC Name:
- Inorganic salts
- Type:
- legal entity composition of the substance
- State Form:
- liquid
Constituent 1
- Reference substance name:
- Active enzyme protein of Subtilisin (EC no. 232-752-2, CAS no. 9014-01-1, EC name: Subtilisin, Enzyme Class no. 3.4.21.62)
- IUPAC Name:
- Active enzyme protein of Subtilisin (EC no. 232-752-2, CAS no. 9014-01-1, EC name: Subtilisin, Enzyme Class no. 3.4.21.62)
Constituent 2
- Reference substance name:
- unknown protein, petides
- IUPAC Name:
- unknown protein, petides
Constituent 3
- Reference substance name:
- impurities based on carbonhydrates
- IUPAC Name:
- impurities based on carbonhydrates
Constituent 4
- Reference substance name:
- impurities based on lipides
- IUPAC Name:
- impurities based on lipides
Constituent 5
- Reference substance name:
- impurities based on inorganic salts
- IUPAC Name:
- impurities based on inorganic salts
- Type:
- legal entity composition of the substance
Constituent 1
- Reference substance name:
- Subtilisin
- EC Number:
- 232-752-2
- EC Name:
- Subtilisin
- CAS Number:
- 9014-01-1
- Molecular formula:
- Not available.
- IUPAC Name:
- Subtilisin
Constituent 2
- Reference substance name:
- Protein as a constituent of enzyme deriving from the fermentation or extraction process
- IUPAC Name:
- Protein as a constituent of enzyme deriving from the fermentation or extraction process
Constituent 3
- Reference substance name:
- Carbohydrates constituent of enzyme deriving from the fermentation or extraction process
- IUPAC Name:
- Carbohydrates constituent of enzyme deriving from the fermentation or extraction process
Constituent 4
- Reference substance name:
- Lipids as a constituent of enzyme deriving from the fermentation or extraction process
- IUPAC Name:
- Lipids as a constituent of enzyme deriving from the fermentation or extraction process
Constituent 5
- Reference substance name:
- Inorganic salts as a constituent of enzyme deriving from the fermentation or extraction process
- IUPAC Name:
- Inorganic salts as a constituent of enzyme deriving from the fermentation or extraction process
- Type:
- legal entity composition of the substance
- State Form:
- solid: bulk
Constituent 1
- Reference substance name:
- Active enzyme protein of Subtilisin (EC no. 232-752-2, CAS no. 9014-01-1, EC name: Subtilisin, Enzyme Class No.: 3.4.21.62)
- IUPAC Name:
- Active enzyme protein of Subtilisin (EC no. 232-752-2, CAS no. 9014-01-1, EC name: Subtilisin, Enzyme Class No.: 3.4.21.62)
Constituent 2
- Reference substance name:
- Protein as a constituent of enzyme deriving from the fermentation or extraction process.
- IUPAC Name:
- Protein as a constituent of enzyme deriving from the fermentation or extraction process.
Constituent 3
- Reference substance name:
- Carbohydrates constituent of enzyme deriving from the fermentation or extraction process
- Molecular formula:
- Not available.
- IUPAC Name:
- Carbohydrates constituent of enzyme deriving from the fermentation or extraction process
Constituent 4
- Reference substance name:
- Lipids as a constituent of enzyme deriving from the fermentation or extraction process
- Molecular formula:
- Not available. See remarks.
- IUPAC Name:
- Lipids as a constituent of enzyme deriving from the fermentation or extraction process
Constituent 5
- Reference substance name:
- Other protein by nitrogen with Kjeldahl method
- IUPAC Name:
- Other protein by nitrogen with Kjeldahl method
Constituent 6
- Reference substance name:
- inorganic salts by sulphated Ash
- IUPAC Name:
- inorganic salts by sulphated Ash
- Type:
- legal entity composition of the substance
- State Form:
- solid: bulk
Constituent 1
- Reference substance name:
- Active enzyme protein of Subtilisin (EC no. 232-752-2, CAS no. 9014-01-1, EC name: Subtilisin, Enzyme Class No.: 3.4.21.62)
- IUPAC Name:
- Active enzyme protein of Subtilisin (EC no. 232-752-2, CAS no. 9014-01-1, EC name: Subtilisin, Enzyme Class No.: 3.4.21.62)
Constituent 2
- Reference substance name:
- Protein as a constituent of enzyme deriving from the fermentation or extraction process
- IUPAC Name:
- Protein as a constituent of enzyme deriving from the fermentation or extraction process
Constituent 3
- Reference substance name:
- Carbohydrates constituent of enzyme deriving from the fermentation or extraction process
- Molecular formula:
- Not available.
- IUPAC Name:
- Carbohydrates constituent of enzyme deriving from the fermentation or extraction process
Constituent 4
- Reference substance name:
- Lipids as a constituent of enzyme deriving from the fermentation or extraction process
- Molecular formula:
- Not available. See remarks.
- IUPAC Name:
- Lipids as a constituent of enzyme deriving from the fermentation or extraction process
Constituent 5
- Reference substance name:
- Other protein by nitrogen with Kjeldahl method
- IUPAC Name:
- Other protein by nitrogen with Kjeldahl method
Constituent 6
- Reference substance name:
- inorganic salts by sulphated Ash
- IUPAC Name:
- inorganic salts by sulphated Ash
- Type:
- boundary composition of the substance
- State Form:
- solid: bulk
Constituent 1
- Reference substance name:
- Active enzyme protein of Subtilisin (EC no. 232-752-2, CAS no. 9014-01-1, EC name: Subtilisin, Enzyme Class No.: 3.4.21.62)
- Molecular formula:
- Not avaiable
- IUPAC Name:
- Active enzyme protein of Subtilisin (EC no. 232-752-2, CAS no. 9014-01-1, EC name: Subtilisin, Enzyme Class No.: 3.4.21.62)
Constituent 2
- Reference substance name:
- Protein as a constituent of enzyme deriving from the fermentation or extraction process
- Molecular formula:
- Not available
- IUPAC Name:
- Protein as a constituent of enzyme deriving from the fermentation or extraction process
Constituent 3
- Reference substance name:
- Carbohydrates constituent of enzyme deriving from the fermentation or extraction process
- Molecular formula:
- Not available.
- IUPAC Name:
- Carbohydrates constituent of enzyme deriving from the fermentation or extraction process
Constituent 4
- Reference substance name:
- Lipids as a constituent of enzyme deriving from the fermentation or extraction process
- Molecular formula:
- Not available.
- IUPAC Name:
- Lipids as a constituent of enzyme deriving from the fermentation or extraction process
Constituent 5
- Reference substance name:
- Inorganic salts as a constituent of enzyme deriving from the fermentation or extraction process
- Molecular formula:
- Not available.
- IUPAC Name:
- Inorganic salts as a constituent of enzyme deriving from the fermentation or extraction process
Registrants / Suppliers Details open all close all
Registrant / Supplier | Registered | Updated | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
BASF SE Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany | 2015 | 2019 | |||||||||||||||||
Beckman Coulter France SAS Paris Nord 2 33 Rue des Vanesses 95942 Roissy CDG CEDE France | 2018 | ||||||||||||||||||
CHT Germany GmbH Bismarckstr. 102 72072 Tuebingen Germany | 2018 | 2018 | |||||||||||||||||
CYGYC BIOCON, S.L. Pol. Ind. Pla de Llerona - C/ Belgica, 5 08520 Les Franqueses del Vallés Spain | 2018 | 2018 | |||||||||||||||||
Genencor International B.V. - OR-US Archimedesweg 30 2333 CN Leiden Netherlands | 2011 | 2016; 2018; 2020 | |||||||||||||||||
Genencor International BVBA Komvest 43 8000 Brugge Belgium | 2011 | 2016; 2019; 2020 | |||||||||||||||||
Genencor International Oy Tiilikantie 15 FI-42300 Jämsänkoski Finland | 2010 | 2016; 2018; 2020 | |||||||||||||||||
Global Product Compliance (Europe) AB IDEON, Beta 5, Scheelevägen 17 22363 Lund Sweden | 2018 | ||||||||||||||||||
Novozymes A/S Krogshoejvej 36 2880 Bagsvaerd Denmark | 2010 | 2010; 2014; 2016; 2017 | |||||||||||||||||
OLON Spa Strada Rivoltana Km 6/7 20053 RODANO Milano Italy | 2019 | ||||||||||||||||||
PHARMEGIC HEALTHCARE LIMITED 6th Floor, Konstitucijos av. 21A, 08130 Vilnius Lithuania Ireland | 2018 | ||||||||||||||||||
ServiREACH, S.A. Rambla Jaume Sabat, 4 08172 Sant Cugat del Vallès Barcelona Spain | 2018 |
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Contact Persons responsible for the SDS
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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