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Solubility in organic solvents / fat solubility

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Reference
Endpoint:
solubility in organic solvents / fat solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
27/12/2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental test result performed using standard test guidelines
Qualifier:
according to guideline
Guideline:
other: as mention below
Principles of method if other than guideline:
The test was conducted to determine the solubility range for which 0.1 gm of substance was dissolved in different solvents like acetone, acetonitrile, methanol, ethanol, toluene and Dimethylformamide (DMF).
GLP compliance:
no
Specific details on test material used for the study:
- Name of test material : Cashew (Anacardium occidentale) Nutshell Extract, Decarboxylated, Distilled
- Common name : Cardanol
- Molecular formula : C84H132O4
- Smiles notation : CCCCCCCCCCCCCCCC1=CC=CC(O)=C1.CCCCCCC\C=C/CCCCCCC1=CC=CC(O)=C1.CCCC\C=C/C\C=C/CCCCCCC1=CC=CC(O)=C1.OC1=CC(CCCCCC\C=C/C\C=C/CCC=C)=CC=C1
- Substance type : Organic
- Physical state : Liquid
Key result
Medium:
other: acetone, acetonitrile, methanol, ethanol, toluene and Dimethylformamide (DMF)
Solubility:
> 1 000 g/L
Remarks on result:
other: Soluble
Test substance stable:
yes
Conclusions:
The solubility range of the substance Cardanol in acetone, acetonitrile, , toluene and DMF was found to be greater than 1000g/l. whereas the solubility range of the substance was determine to be in the range of 200 – 1000g/l in case of methanol and ethanol respectively
Executive summary:

The solubility determination of test substance Cardanol(EC no.: 700 -991 -6) in various organic solvents was done with acetone, acetonitrile, methanol, ethanol, toluene and Dimethylformamide (DMF). The solubility of the test substance in acetone, acetonitrile, toluene and DMF was determine to be greater than 1000 g/l whereas the solubility value in methanol and ethanol was determine to be in the range of 200 – 1000g/l respectively at 24.2 °C.

Description of key information

The solubility determination of test substance Cardanol(EC no.: 700 -991 -6) in various organic solvents was done with acetone, acetonitrile, methanol, ethanol, toluene and Dimethylformamide (DMF). The solubility of the test substance in acetone, acetonitrile, toluene and DMF was determine to be greater than 1000 g/l whereas the solubility value in methanol and ethanol was determine to be in the range of 200 – 1000g/l respectively at 24.2 °C.

Key value for chemical safety assessment

Solubility in organic solvents at 20°C:
1 000 g/L

Additional information

The solubility determination of test substance Cardanol(EC no.: 700 -991 -6) in various organic solvents was done with acetone, acetonitrile, methanol, ethanol, toluene and Dimethylformamide (DMF). The solubility of the test substance in acetone, acetonitrile, toluene and DMF was determine to be greater than 1000 g/l whereas the solubility value in methanol and ethanol was determine to be in the range of 200 – 1000g/l respectively at 24.2 °C.