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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Remarks:
The study was conducted to Good Laboratory Practice.
Qualifier:
according to guideline
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
effusion method: vapour pressure balance
Specific details on test material used for the study:
dark brown sligthly viscous liquid
storage conditions: room temperature in the dark
Temp.:
25 °C
Vapour pressure:
0 Pa
Transition / decomposition:
no

Table 1: Results from the first run

Temp. (°C)

Temp. (K)

Reciprocal temp. (K-1)

Mass difference (µg)

Mass difference (kg)

Vapour pressure (Pa)

Log10Vp

90

363.15

0.002753683

38.47

3.847 x10-8

0.053406216

-1.272408192

91

364.15

0.002746121

40.27

4.027 x10-8

0.055905077

-1.252548749

92

365.15

0.002738601

44.03

4.403 x10-8

0.061124920

-1.213781693

93

366.15

0.002731121

46.77

4.677 x10-8

0.064928742

-1.187563009

94

367.15

0.002723682

49.44

4.944 x10-8

0.068635386

-1.163451917

95

368.15

0.002716284

53.63

5.363 x10-8

0.074452180

-1.128122582

96

369.15

0.002708926

57.96

5.796 x10-8

0.080463329

-1.094402002

97

370.15

0.002701607

64.96

6.496 x10-8

0.090181123

-1.044884362

98

371.15

0.002694328

69.14

6.914 x10-8

0.095984034

-1.017801004

99

372.15

0.002687089

78.02

7.802 x10-8

0.108311749

-0.965324433

100

373.15

0.002679887

85.89

8.589 x10-8

0.119237325

-0.923587776

Table 2: Results from the second run

Temp. (°C)

Temp. (K)

Reciprocal temp. (K-1)

Mass difference (µg)

Mass difference (kg)

Vapour pressure (Pa)

Log10Vp

90

363.15

0.002753683

37.82

3.782 x10-8

0.052503849

-1.279808854

91

364.15

0.002746121

40.92

4.092 x10-8

0.056807444

-1.245594754

92

365.15

0.002738601

43.45

4.345 x10-8

0.060319732

-1.219540598

93

366.15

0.002731121

48.36

4.836 x10-8

0.067136070

-1.173044087

94

367.15

0.002723682

51.75

5.175 x10-8

0.071842258

-1.143620025

95

368.15

0.002716284

55.00

5.500 x10-8

0.076354091

-1.117167689

96

369.15

0.002708926

60.99

6.099 x10-8

0.084669746

-1.072271745

97

370.15

0.002701607

66.26

6.626 x10-8

0.091985856

-1.036278947

98

371.15

0.002694328

73.48

7.348 x10-8

0.102009065

-0.991361231

99

372.15

0.002687089

79.97

7.997 x10-8

0.111018848

-0.954603283

100

373.15

0.002679887

87.62

8.762 x10-8

0.121639008

-0.914927130

Table 3: Results from the third run

Temp. (°C)

Temp. (K)

Reciprocal temp. (K-1)

Mass difference (µg)

Mass difference (kg)

Vapour pressure (Pa)

Log10Vp

91

364.15

0.002746121

41.28

4.128 x10-8

0.057307216

-1.241790690

92

365.15

0.002738601

44.32

4.432 x10-8

0.061527515

-1.210930627

93

366.15

0.002731121

47.85

4.785 x10-8

0.066428059

-1.177648437

94

367.15

0.002723682

52.04

5.204 x10-8

0.072244853

-1.141193091

95

368.15

0.002716284

56.80

5.680 x10-8

0.078852952

-1.103182043

96

369.15

0.002708926

61.57

6.157 x10-8

0.085474934

-1.068161225

97

370.15

0.002701607

68.64

6.864 x10-8

0.095289905

-1.020953104

98

371.15

0.002694328

74.77

7.477 x10-8

0.103799916

-0.983802998

99

372.15

0.002687089

82.50

8.250 x10-8

0.114531136

-0.941076430

100

373.15

0.002679887

90.29

9.029 x10-8

0.125345652

-0.901890726

Table 4: Results from the fourth run

Temp. (°C)

Temp. (K)

Reciprocal temp. (K-1)

Mass difference (µg)

Mass difference (kg)

Vapour pressure (Pa)

Log10Vp

90

363.15

0.002753683

38.40

3.840 x10-8

0.053309038

-1.273199154

91

364.15

0.002746121

41.72

4.172 x10-8

0.057918049

-1.237186079

92

365.15

0.002738601

44.89

4.489 x10-8

0.062318821

-1.205380773

93

366.15

0.002731121

49.15

4.915 x10-8

0.068232792

-1.166006857

94

367.15

0.002723682

53.05

5.305 x10-8

0.073646991

-1.132844990

95

368.15

0.002716284

58.97

5.897 x10-8

0.081865468

-1.086899251

96

369.15

0.002708926

62.65

6.265 x10-8

0.086974251

-1.060609303

97

370.15

0.002701607

69.65

6.965 x10-8

0.096692044

-1.014609258

98

371.15

0.002694328

76.80

7.680 x10-8

0.106618076

-0.972169159

99

372.15

0.002687089

84.95

8.495 x10-8

0.117932364

-0.928366996

100

373.15

0.002679887

92.39

9.239 x10-8

0.128260990

-0.891905412

Table 5: Results from the fifth run

Temp. (°C)

Temp. (K)

Reciprocal temp. (K-1)

Mass difference (µg)

Mass difference (kg)

Vapour pressure (Pa)

Log10Vp

90

363.15

0.002753683

39.26

3.926 x10-8

0.054502938

-1.263580083

91

364.15

0.002746121

42.51

4.251 x10-8

0.059014771

-1.229039274

92

365.15

0.002738601

45.47

4.547 x10-8

0.063124009

-1.199805425

93

366.15

0.002731121

47.71

4.771 x10-8

0.066233703

-1.178920962

94

367.15

0.002723682

53.55

5.355 x10-8

0.074341119

-1.128770904

95

368.15

0.002716284

58.68

5.868 x10-8

0.081462874

-1.089040274

96

369.15

0.002708926

64.02

6.402 x10-8

0.088876162

-1.051214709

97

370.15

0.002701607

70.15

7.015 x10-8

0.097386172

-1.011502703

98

371.15

0.002694328

77.52

7.752 x10-8

0.107617621

-0.968116615

99

372.15

0.002687089

83.87

8.387 x10-8

0.116433047

-0.933923736

100

373.15

0.002679887

91.09

9.109 x10-8

0.126456257

-0.898059677

Table 6: Summary of results

Run

Log10 [Vp (25°)]

1

-4.125

2

-4.259

3

-4.412

4

-4.399

5

-4.318

Mean

-4.303

Vapour pressure

5 x10-5Pa

Conclusions:
The test material did not change in appearance under the conditions used in the determination. The vapour pressure of Cashew (Anacardium occidentale) Nutshell Extract, Decarboxylated, Distilled (Distilled Grade) was determined to be 0.00005 Pa at 25°C in an OECD Guideline 104 study, conducted under GLP conditions.
Executive summary:

The vapour pressure of Cashew nutshell liquid (measured using a distilled grade CNSL sample) was determined in an OECD 104 Vapour Pressure test. This study was conducted to Good Laboratory Practice.

The vapour pressure was determined using a vapour pressure balance system with measurements being made at several temperatures and a linear regression analysis analysis used to calculate the vapour pressure at 25°C. A sequence of runs was conducted after a sample of test material had been under vacuum for approximately 19.5 hours. Temperature and pressure readings were taken between 90 and 100°C with a one hour dwell at 90°C between runs.

The vapour pressure was determined to be 5 x10-5 Pa at 25°C.

This study is classified acceptable and satisfies the guideline requirement for a vapour pressure study.

Description of key information

The test material did not change in appearance under the conditions used in the determination. The vapour pressure of Cashew (Anacardium occidentale) Nutshell Extract, Decarboxylated, Distilled (Distilled Grade)  was determined to be 0.00005 Pa at 25°C in an OECD Guideline 104 study, conducted under GLP conditions.

Key value for chemical safety assessment

Vapour pressure:
0 Pa
at the temperature of:
25 °C

Additional information

The vapour pressure of Cashew nutshell Extract, Decarboxylated, Distilled (Distilled Grade) was determined in an OECD 104 vapour pressure test. This study was conducted to Good Laboratory Practice. The vapour pressure was determined to be 0.00005 Pa at 25°C. This study is classified acceptable and satisfies the guideline requirement for a vapour pressure study.