Registration Dossier
Registration Dossier
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EC number: 201-176-3 | CAS number: 79-09-4
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- repeated dose toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Due to major deficiencies in presentation of the data the study is considered to be not valid
Data source
Reference
- Reference Type:
- publication
- Title:
- Die biologische Wirkung von Propionaldehyd und Propionsaeure auf den Organismus von Versuchstieren
- Author:
- Melnikowa AP and Tokanowa SE
- Year:
- 1 983
- Bibliographic source:
- Gig.Sanit. 4, 74-76 (1983) german translation
Materials and methods
Test material
- Reference substance name:
- Propionic acid
- EC Number:
- 201-176-3
- EC Name:
- Propionic acid
- Cas Number:
- 79-09-4
- Molecular formula:
- C3H6O2
- IUPAC Name:
- propanoic acid
- Details on test material:
- - Name of test material (as cited in study report): Propionsaeure
- Source:
- Analytical purity:
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: adult (no further data)
- Weight at study initiation: 140 -160 g
- Fasting period before study:
- Housing: no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS: no data
Administration / exposure
- Route of administration:
- inhalation
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 3 months
- Frequency of treatment:
- "continuous exposure"
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.017, 0.17 und 1.7 mg/m3
Basis:
no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: Yes
- Time schedule: no data
- Cage side observations checked: general state, behaviour
BODY WEIGHT: Yes
- Time schedule for examinations: no data
HAEMATOLOGY: Yes
- Time schedule for collection of blood: no data
- Parameters checked: leucocyte number, erythrocyte number, hemoglobin
CLINICAL CHEMISTRY: Yes
- Time schedule for collection of blood: no data
- Parameters checked: cholinesterase - Sacrifice and pathology:
- GROSS PATHOLOGY: Yes (organ weights were also taken. No data which organs were weighed)
HISTOPATHOLOGY: Yes
- Organs prepared: heart, lungs, liver, kidneys and spleen
Results and discussion
Results of examinations
- Details on results:
- Changes in lung tissue, bronchitis, peribronchitis, desquamation. The rather poor presentation of further systemic effects is not usable.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
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