Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-020-6 | CAS number: 627-93-0
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- April-June 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- This IUCLID for dimethyl adipate is compiled using data from the substance itself, a structurally related compound (dimethyl glutarate) and a mixture of dibasic esters (dimethyl adipate, succinate and glutarate). The phys-chem properties of each of these substances are rather similar and the document attached justifies why data on the category members can be used to support the data gaps for dimethyl adipate.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- 1.4
- Temp.:
- 22 °C
- pH:
- 6.9
- Conclusions:
- The log Pow for dimethyl adipate is 1.4.
- Executive summary:
During this study the partition coefficient (n-octanol / water) of Reaction mass of Dimethyl adipate (CAS 627-93-0), Dimethyl glutarate (CAS 1119-40-0) and Dimethyl succinate (CAS 106-65-0) was determined using the HPLC- method as described in EEC Directive 92/69, A.8 “Partition Coefficient” (2008), the Council Regulation (EC) No. 440/2008, A.8 and in the OECD Guideline No. 117, “Partition Coefficient (n-Octanol / Water), High Performance Liquid Chromatography (HPLC) method” (2004).
Six common standards, which have known log POW values were used as reference standards. For the determination of the dead time a thiourea solution was used. From the regression curve (log k' vs. log POW) the n-octanol / water partition coefficient (log POW) of Reaction mass of Dimethyl adipate (CAS 627-93-0), Dimethyl glutarate (CAS 1119-40-0) and Dimethyl succinate (CAS 106-65-0) at 22 °C was calculated to be
log Pow = 1.4 for Dimethyl adipate (CAS 627-93-0)
log Pow = 0.6 for Dimethyl succinate (CAS 106-65-0)
log Pow = 1.0 for Dimethyl glutarate (CAS 1119-40-0)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Peer reviewed reference book.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- GLP compliance:
- no
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Type:
- log Pow
- Partition coefficient:
- 1.03
- Temp.:
- 25 °C
- Remarks on result:
- other: The pH was neutral (6 - 8) and for a non ionizable substance such as this one, this parameter is not critical.
Referenceopen allclose all
Description of key information
The partition coefficient between octanol and water is 1.4.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 1.4
- at the temperature of:
- 22 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
