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EC number: 211-020-6 | CAS number: 627-93-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Justification for type of information:
- This IUCLID for dimethyl adipate is compiled using data from the substance itself, a structurally related compound (dimethyl glutarate) and a mixture of dibasic esters (dimethyl adipate, succinate and glutarate). The toxicity of each of these substances is similar and the document attached justifies why data on the category members can be used to support the data gaps for dimethyl adipate.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not applicable
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Dimethyl adipate
- EC Number:
- 211-020-6
- EC Name:
- Dimethyl adipate
- Cas Number:
- 627-93-0
- Molecular formula:
- C8H14O4
- IUPAC Name:
- dimethyl adipate
- Reference substance name:
- Hexanedioic acid, dimethyl ester
- IUPAC Name:
- Hexanedioic acid, dimethyl ester
- Details on test material:
- - Name of test material (as cited in study report): H-24926
- Physical state: clear liquid
- Impurities (identity and concentrations): Trace amounts of hydrogen cyanide (< 2 ppm)
- Composition of test material, percentage of components: > 98.5% Dimethyl adipate, < 0.1% Dimethyl succinate
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Covance Research Products, Denver, Pennsylvania
- Age at study initiation: adults
- Weight at study initiation: 1584.7 to 2230.2 grams
- Housing: The rabbits were housed singly in suspended, stainless steel, wire-mesh cages.
- Diet: The rabbits were offered approximately 125 grams of PMI Nutrition International, Inc. Certified High Fiber Rabbit LabDiet 5325 daily during the study.
- Water: ad libitum
- Acclimation period: 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20°C ± 1°C
- Humidity (%): 50% ± 10%.
- Photoperiod (hrs dark / hrs light): 12-hour light/12-hour dark cycle
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: The area to be treated (approximately 6" x 5") was outlined on the skin of each rabbit's back with a water-insoluble marker. The aliquot of test substance designated for an animal was spread evenly, directly on the skin, covering an area of approximately 190 square centimeters.
- % coverage: approximately 10 percent of the total body surface area of rabbits in the 2 - 3 kg body weight range.
- Type of wrap if used: The test substance was covered with a 2-ply gauze patch. The rabbits were then wrapped with stretch gauze bandage and elastic adhesive bandage. This procedure was followed for each of 5 male and 5 female rabbits. After wrapping, the rabbits were returned to their cage.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Approximately 24 hours after treatment, the rabbits were removed from their cages, and the wrappings were removed. Excess test substance was washed from the animals' backs with warm water, and the skin was dried with a paper towel.
- Time after start of exposure: 24 hours after treatment
TEST MATERIAL
- H-24926 was measured for each animal on the day of treatment at a dose of 1000 mg/kg of body weight. The amount of test substance designated for an animal was calculated based on body weights collected prior to treatment and the test substance density of 1064 mg/mL. - Duration of exposure:
- 24 hours
- Doses:
- 1000 mg/kg body weight
- No. of animals per sex per dose:
- 5 male + 5 female
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Approximately 24 hours after treatment, the rabbits were removed from their cages, and the wrappings were removed. Excess test substance was washed from the animals' backs with warm water, and the skin was dried with a paper towel. Approximately 1 hour after removal of the test substance, the rabbits were weighed, observed for clinical signs of toxicity and dermal response, and returned to their cages. Dermal effects were scored according to the Draize Scale.
- Necropsy of survivors performed: no - Statistics:
- none
Results and discussion
- Preliminary study:
- not applicable
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: highest dose tested
- Mortality:
- No mortality was observed
- Clinical signs:
- other: The rabbits exhibited no clinical signs of toxicity
- Gross pathology:
- not performed
- Other findings:
- none
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Under the conditions of this test, the skin absorption LD50 for H-24926 was greater than 1000 mg/kg of body weight for male and female rabbits and according to Annex VI of the Directive 67/548/CEE and according to EU Regulation 1272/2008 (CLP) would not be classified.
- Executive summary:
A single dose of H-24926 was applied to the shaved, intact skin of 5 male and 5 female rabbits at a dose of 1000 mg/kg of body weight. The application site was semi-occluded for 24 hours, after which the test substance was removed. Observations during the 15-day test period included daily mortality checks, body weight determinations, and observations for clinical signs of toxicity and dermal irritation. No deaths occurred. The rabbits exhibited no clinical signs of toxicity or dermal irritation. Body weight loss of approximately 2-6% of initial weight occurred in 5 rabbits by the day after application of the test substance.
Under the conditions of this test, the skin absorption LD50 for H-24926 was greater than 1000 mg/kg of body weight for male and female rabbits.
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