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EC number: 211-020-6 | CAS number: 627-93-0
- Life Cycle description
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- Endpoint summary
- Appearance / physical state / colour
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- Boiling point
- Density
- Particle size distribution (Granulometry)
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- Water solubility
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- Auto flammability
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- Additional physico-chemical information
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- Endpoint summary
- Stability
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- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
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- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
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- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Neither classified as a skin or eye irritant
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- January 09 to March 02, 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- This IUCLID for dimethyl adipate is compiled using data from the substance itself, a structurally related compound (dimethyl glutarate) and a mixture of dibasic esters (dimethyl adipate, succinate and glutarate). The toxicity of each of these substances is similar and the document attached justifies why data on the category members can be used to support the data gaps for dimethyl adipate.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: L'Abbaye de Bellefontaine, F-49122 Begrolles en Mauges, France
- Weight at study initiation: 2.5 ± 0.1 kg
- Housing: Individually in polystyrene cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 6 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ±3 °C
- Humidity (%): 50 ± 20
- Photoperiod (hrs dark / hrs light): 12/12 - Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit):0.5 ml - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1h, 24h, 48 h, and 72 h after exposure termination;
- Number of animals:
- 3 animals
- Details on study design:
- TEST SITE
- Area of exposure: right flank
- coverage: 6 cm²
- Type of wrap if used: gauze patch held in place with semi-occlusive dressing
SCORING SYSTEM:
Erythema score: 0-4
Edema score: 0-4 - Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- no indication of irritation
- Interpretation of results:
- not irritating
- Conclusions:
- Under the conditions of this assay, the test article has no skin irritating potential.
- Executive summary:
DBE has been tested for skin irritation on 3 New Zealand White rabbits according to OECD guideline n° 404 and EU guideline n° B.4 (Draize Method) in compliance with Good Laboratory Practice. The rabbits received a dermal dose of 0.5 ml of DBE on a gauze on intact and abraded skin sites under an semiocclusive dressing for a period of 24 hours. Scores for erythema and oedema were measured 1, 24, 48 and 72 hours after patch removal and primary cutaneous index was calculated (maximum possible index =12). No sign of dermal irritation (score = 0 for erythema and oedema) was observed for intact skin site of the 3 rabbits at any reading time. Primary Irritation Index was = 0.0. No other signs of intoxication were observed.
Based on these results DBE is not classified irritating to skin according to the criteria of the Directive 67/548/CEE and according to EU Regulation 1272/2008 (CLP).
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Study period:
- April 2, 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study did not evaluate irritation but limited its observation to corrosion over a period of 48 hours.
- Justification for type of information:
- This IUCLID for dimethyl adipate is compiled using data from the substance itself, a structuraly related compound (dimethyl glutarate) and a mixture of dibasic esters (dimethyl adipate, succinate and glutarate). The toxicity of each of these susbtances is similar and the document attached justifies why data on the category members can be used to support the data gaps for dimethyl adipate.
- Qualifier:
- according to guideline
- Guideline:
- other: US Department of Transportation 49 CFR 173.240
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- Albino rabbits (n=6) weighing 2-3 kg
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 mL = 0.5 g (assuming density of 1).
Density of structurally similar substance, DBE (EC#906 -170 -0), is 1.0915. - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 48 hours
- Number of animals:
- 6 rabbits
- Details on study design:
- Six albino rabbits, weighing between 2-3 kg, were shaved dorsally and placed into FDA-type stocks. The test material, 0.5 mL, was applied under a 1.5 x 1.5 inch, 12-ply cotton gauze pad and the trunk of each animal was loosely fitted with rubber sheeting. After 4 hours, the rabbits were removed from the stocks, the wrappings and gauze were removed and any skin reactions were evaluated. The test sites were washed and re-evaluated at 24 and 48 hours for corrosion.
- Irritation parameter:
- other: corrosion
- Basis:
- mean
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no corrosion observed
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- 0/6 animals exhibited corrosion.
- Other effects:
- Not evaluated
- Conclusions:
- The material is not corrosive to skin according to US Department of Transportation 49 CFR 173.240(a)(1).
- Executive summary:
Six albino rabbits, weighing between 2-3 kg, were shaved dorsally and placed into FDA-type stocks. The test material, 0.5 mL, was applied under a 1.5 x 1.5 inch, 12-ply cotton gauze pad and the trunk of each animal was loosely fitted with rubber sheeting. After 4 hours, the rabbits were removed from the stocks, the wrappings and gauze were removed and any skin reactions were evaluated. The test sites were washed and re-evaluated at 24 and 48 hours for corrosion.
The material is not corrosive to skin according to US Department of Transportation 49 CFR 173.240(a)(1).
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- an in vitro skin irritation study does not need to be conducted because adequate data from an in vivo skin irritation study are available
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- EPA OTS 798.4470 (Acute Dermal Irritation)
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 24, 48, 72 hours
- Number of animals:
- 6 (3m/3f)
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Average Dermal Irritation Score (ADIS) was 0.0. No irritation was observed. This material would probably not be considered to produce dermal irritation as defined in EPA Guidelines.
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Study period:
- January 31 to February 02, 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Justification for type of information:
- This IUCLID for dimethyl adipate is compiled using data from the substance itself, a structurally related compound (dimethyl glutarate) and a mixture of dibasic esters (dimethyl adipate, succinate and glutarate). The toxicity of each of these substances is similar and the document attached justifies why data on the category members can be used to support the data gaps for dimethyl adipate.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- 24-hour occlusive application (more stringent exposure conditions)
- GLP compliance:
- yes
- Remarks:
- quality assurance documentation provided
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Young adult male and female New Zealand White rabbits were received from Hare Marland, Hewitt; New Jersey. The rabbits were housed singly in
suspended, stainless steel, wire-mesh cages. Each rabbit was assigned a unique identification number which was recorded on a card affixed to the
cage. Purina Certified High Fiber Rabbit Chowand water were available ad libidum except as noted under Protocol. Rabbits were quarantined, weighed and observed for general health for approximately 2 weeks. Animal rooms were maintained on a timer-controlled, 12-hour light/12-hour dark cycle. Environmental conditions of the rooms were targeted for a temperature of 20°C +/- 2°C and relative humidity of 50% +/- 10%. Any excursions outside these ranges were of small magnitude and/or brief duration and did not adversely affect the validity of the study. - Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit):0.5 mL
- Concentration (if solution): not specified - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 h, 48 h, 72 h after the end of application
- Number of animals:
- 6 animals per group
- Details on study design:
- TEST SITE
- Area of exposure: scapular to lumbar region of back
- % coverage: not specified
- Type of wrap if used: rubber sheeting
REMOVAL OF TEST SUBSTANCE
- Washing (if done): yes,
- Time after start of exposure: 24 hours - Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 24 h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 24 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 24 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- other: 24 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 72 h
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- other: 24 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- other: 24 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 48 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 48 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 48 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- other: 48 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 72 h
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- other: 48 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- other: 48 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- other: 72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- other: 72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not reversible
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- other: 72 h
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- other: 72 h
- Score:
- 1
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 72 h
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- other: 72 h
- Score:
- 0
- Max. score:
- 2
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- other: 72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Other effects:
- No edema was observed exept for animal No. 6, which showed slight (score 1) edema 48 hours and 72 hours after exposure.
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Under the conditions of this study, DBE was considered as highly irritant based on its capacity to induce moderate to severe erythema.
- Executive summary:
A skin irritation test was performed similar to OECD Guideline 404 and EPA GLP conditions. Approximately 0.5 mL aliquots of DBE were applied directly on the test sites of 3 male and 3 female New Zealand White rabbits closely clipped to expose the skin. Wrapping was used to retard evaporation and to keep the test material in contact with the skin without undue pressure.
Approximately 24, 48 and 72 hours after application of the test material, the test sites were evaluated for erythema, edema and other evidence of dermal effects and were scored according to the Draize Scale. The adjacent areas of the untreated skin were used for comparison.
DBE produced moderate erythema in one rabbit; mild erythema in 4 rabbits and no erythema in one rabbit 24 hours after treatment. No edema was present. By 48 hours after treatment; 2 rabbits exhibited moderate erythema and 4 rabbits exhibited no to mild erythema; one rabbit had slight edema. By 72 hours, one rabbit exhibited severe erythema with fissuring and slight edema. No to mild erythema and no edema were observed in the other 5 rabbits. One rabbit exhibited no dermal irritation throughout the study.
Under the conditions of this study, DBE was considered as highly irritant based on its capacity to induce moderate to severe erythema.
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1975
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to Department of Transportation Skin Corrosion Test on rabbit skin and limited information is available.
- Justification for type of information:
- This IUCLID for dimethyl adipate is compiled using data from the substance itself, a structuraly related compound (dimethyl glutarate) and a mixture of dibasic esters (dimethyl adipate, succinate and glutarate). The toxicity of each of these susbtances is similar and the document attached justifies why data on the category members can be used to support the data gaps for dimethyl adipate.
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- other: Department of Transportation, Hazardous Materials Regulations, title 49 CFR, Section 173.240(a)(1), December 31, 1973
- Deviations:
- not specified
- Principles of method if other than guideline:
- equivalent or similar to OECD TG 404
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: young adults
- Weight at study initiation: 2-3 kg - Type of coverage:
- occlusive
- Preparation of test site:
- other: test sites were clipped free of fur
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 4 hours after application, 24 and 48 hours after the application
- Number of animals:
- six
- Details on study design:
- Six albino rabbits weighing between 2-3 kg were clipped free of hair on the back and placed in FDA-type stocks. 0.5 ml of the test material (as supplied) was applied under 1.5 x 1.5 inch, 12-ply cotton gauze pads and the trunk of each rabbit was then loosely wrapped with rubber sheeting. After 4 hours, the rabbits were removed from the stocks, the wrapping and gauze pads were removed and any skin reactions were evaluated. The test sites were then washed. Readings were again made at 24 and 48 hours afte the initial application
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 4, 24 and 48 hours after application
- Score:
- 0
- Irritant / corrosive response data:
- None of the animals exposed to adipic acid, dimethyl ester exhibited any signs of corrosion.
- Other effects:
- none
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Department of Transportation, Hazardous Materials Regulations, title 49 CFR, Section 173.240(a)(1), December 31, 1973
- Conclusions:
- When tested and classified according to the regulations of the Department of Transportation, adipic acid, dimethyl ester was not found to be corrosive to rabbit skin.
- Executive summary:
This skin corrosion study on rabbits was conducted according to Department of Transportation, Hazardous Materials Regulations, title 49 CFR, Section 173.240(a)(1), December 31, 1973. Six albino rabbits weighing between 2-3 kg were clipped free of hair on the back and placed in FDA-type stocks. 0.5 ml of the test material (as supplied) was applied under 1.5 x 1.5 inch, 12-ply cotton gauze pads and the trunk of each rabbit was then loosely wrapped with rubber sheeting. After 4 hours, the rabbits were removed from the stocks, the wrapping and gauze pads were removed and any skin reactions were evaluated. The test sites were then washed. Readings were again made at 24 and 48 hours afte the initial application.
When tested and classified according to the regulations of the Department of Transportation, adipic acid, dimethyl ester was not found to be corrosive to rabbit skin.
Referenceopen allclose all
Average Dermal Irritation Score (ADIS) was 0.0. No irritation was
observed. This material would probably not be considered to produce
dermal irritation as defined in EPA Guidelines.
DBE produced moderate erythema in one rabbit; mild erythema in 4 rabbits and no erythema in one rabbit 24 hours after treatment. No edema was present. By 48 hours after treatment; 2 rabbits exhibited moderate erythema and 4 rabbits exhibited no to mild erythema; one rabbit had slight edema. By 72 hours, one rabbit exhibited severe erythema with fissuring and slight edema. No to mild erythema and no edema were observed in the other 5 rabbits. One rabbit exhibited no dermal irritation throughout the study. All rabbits exhibited red swollen nictitating membranes and a milky-white
ocular discharge during the study. Since 3 other test materials were tested concurrently with DBE (each material applied to a separate test site); these clinical signs cannot be specifically attributed to DBE. A summary of responses is presented in the following table.
Summary of Skin Responses to DBE |
||||||
Erythema |
Edema |
|||||
Response |
24 hr |
48 hr |
72 hr |
24 hr |
48 hr |
72 hr |
No Response |
1/6 |
1/6 |
2/6 |
6/6 |
5/6 |
5/6 |
Slight |
0/6 |
1/6 |
1/6 |
0/6 |
1/6 |
1/6 |
Mild |
4/6 |
2/6 |
2/6 |
0/6 |
0/6 |
0/6 |
Moderate |
1/6 |
2/6 |
0/6 |
0/6 |
0/6 |
0/6 |
Severe |
0/6 |
0/6 |
1/6 |
0/6 |
0/6 |
0/6 |
None
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation:
The available skin irritation studies for DMA, DMG and the mix of dibasic esters show that this substance is not irritating to the skin.
Eye irritation:
The available Eye irritation data on DMA are inconsistent and unfortunately there is either minimum information available in the report or the study is only reported in summary form on the EPA website. However it does appear that DMA can be irritating to some extent to the eyes, albeit reversible irritation.
Looking at the more comprehensive studies available for the Dibasic esters it appears that these arr also irritating to some degree but do not meet the criteria for classification in the EU as irritating to the eyes.
Given the larger number of studies (reported in more detail) for the DBE, and given that DMA is a component of DBE, it is considered that DMA would be mildly irritating, but not classified as irritating to the eyes.
Respiratory irritation:
No studies are available that assess respiratory irritation specifically. However in a 90-day repeated dose inhalation study with DMA there was evidence of local cyctotoxicity in the upper respiratory tract at 400 ppm.
Justification for selection of skin irritation / corrosion endpoint:
Study according to OECD Guideline 404 under GLP .
Justification for selection of eye irritation endpoint:
Study according to OECD Guideline 405 under GLP .
Justification for classification or non-classification
The incidence and severity of the signs of irritation observed among those different studies were below the criteria of Annex VI Directive 67/548/EEC or EU Regulation 1272/2008 (CLP), therefore warranting no classification for respiratory, skin or eye irritation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
