Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 249-951-5 | CAS number: 29911-28-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- February-July 1987
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to OECD guideline
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- n/a
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1-(2-butoxy-1-methylethoxy)propan-2-ol
- EC Number:
- 249-951-5
- EC Name:
- 1-(2-butoxy-1-methylethoxy)propan-2-ol
- Cas Number:
- 29911-28-2
- Molecular formula:
- C10H22O3
- IUPAC Name:
- 1-(2-butoxy-1-methylethoxy)propan-2-ol
- Details on test material:
- Identity: Dowanol-DPnB (n-butoxypropoxypropanol or
dipropylene glycol normal-butyl ether).
CAS # 29911-28-2
Batch No.: XZ 95411.00
Purity: "More than 95%"
Supplied as: Not reported.
Appearance: Clear liquid.
Administered as: Undiluted liquid.
Specific Gravity: 0.91 kg/liter.
Solubility: 5% in water.
Stability: Stable up to 200°C.
Storage: At ambient temperature in the dark.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Wiga GmbH
- Age at study initiation: approximately 8 weeks
- Weight at study initiation: 225-304 g (males), 172-201 g (females)
- Fasting period before study: feed was withheld overnight before dosing
- Housing: individually housed in polycarbonate cages 7 days prior to dosing
- Diet (e.g. ad libitum): ad libitum, standard laboratory animal diet (RMH-B)
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-23
- Humidity (%): 50-70%
- Air changes (per hr): n/a
- Photoperiod (hrs dark / hrs light): 12 hrs dark/ 12 hrs light
IN-LIFE DATES: From: 1987-Feb-17 (range-finding) and 1987-Feb-24 To: 1987-Feb-24 (range finding) and 1987-March-10
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: n/a
- Amount of vehicle (if gavage): n/a
- Justification for choice of vehicle: n/a
- Lot/batch no. (if required): n/a
- Purity: n/a
MAXIMUM DOSE VOLUME APPLIED: 20 ml/kg bw for aqueous material
DOSAGE PREPARATION (if unusual): n/a
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: n/a - Doses:
- 3200, 4200 and 5600 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily clinical observation except for weekends (observe for death only), Body weights were recorded prior to dosing, at death, or weekly thereafter.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- n/a
Results and discussion
- Preliminary study:
- n/a
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 000 mg/kg bw
- 95% CL:
- 3 200 - 4 600
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 4 400 mg/kg bw
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 3 700 mg/kg bw
- 95% CL:
- 2 500 - 4 800
- Mortality:
- At the low dose of 3200 mg/kg DPnB, one male died on day 0 and one female died on day one (total mortality 2/10). At 4200 mg/kg, two males and two females died on day 0 and two additional females died on day 1 (total mortality 6/10). At 5600 mg/kg, four males and four females died on day 0 and one additional female died on day 1 (total mortality 9/10).
All deaths occurred within two days of dosing. Females were affected more than males. - Clinical signs:
- other: Adverse signs included weight loss, lethargy, coma, hypopnea, hyperpnea, dacryorrhea, blood around the eyes, rough coat, and ataxia. Surviving rats showed no adverse signs by day 2.
- Gross pathology:
- At necropsy, (presumably non-surviving) rats showed 1) enlargement, hemorrhage, and hyperemia of the stomach, 2) hemorrhage of the thymus, 3) dark red lungs, 4) dark red liver, and 5) gas accumulation, bloody content, and watery content of the small intestine.
- Other findings:
- - Organ weights: n/a
- Histopathology: n/a
- Potential target organs: n/a
- Other observations: n/a
Any other information on results incl. tables
The calculated oral LD50 for males alone was 4400 mg/kg (no
95% confidence limits), for females alone was 3700 mg/kg
(95% CL: 2500 - 4800 mg/kg), and for both sexes combined was
4000 mg/kg (95% CL: 3200 - 4600 mg/kg).
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- The substance is not classified for acute oral toxicity according to EU criteria as the lowest LD50 is 3700 mg/kg.
- Executive summary:
Three groups of Wistar rats (5/sex/dose level) received single oral doses of 3200, 4200, or 5600 mg/kg dipropylene glycol n-butyl ether (DPnB), administered undiluted using a stainless steel stomach cannula attached to a syringe.
Animals were fasted overnight prior to dosing and were not allowed food until 4.5-5.0 hr after dosing. Subjects were observed for mortality and signs of toxicity several times on the day of dosing (Day 0) and on weekdays thereafter for
up to 14 additional days. Body weights were recorded prior to dosing, at death, or weekly thereafter.Non-survivors were necropsied as soon as possible and surviving animals were sacrificed by CO2 asphyxiation and subjected to necropsy on day 15.
At the low dose of 3200 mg/kg DPnB, one male died on day 0 and one female died on day one (total mortality 2/10). At
4200 mg/kg, two males and two females died on day 0 and two additional females died on day 1 (total mortality 6/10). At
5600 mg/kg, four males and four females died on day 0 and one additional female died on day 1 (total mortality 9/10).The calculated oral LD50 for males alone was 4400 mg/kg (no 95% confidence limits), for females alone was 3700 mg/kg
(95% CL: 2500 - 4800 mg/kg), and for both sexes combined was 4000 mg/kg (95% CL: 3200 - 4600 mg/kg).
All deaths occurred within two days of dosing. Females were affected more than males. Adverse signs included weight loss, lethargy, coma, hypopnea, hyperpnea, dacryorrhea, blood around the eyes, rough coat, and ataxia. Surviving rats showed no adverse signs by day 2. Weight gain appeared normal in survivors. At necropsy, (presumably non-surviving) rats showed 1) enlargement, hemorrhage, and hyperemia of the stomach, 2) hemorrhage of the thymus, 3) dark red lungs, 4) dark red liver, and 5) gas accumulation, bloody content, and watery content of the small intestine.The calculated oral LD50 for males alone was 4400 mg/kg (no 95% confidence limits), for females alone was 3700 mg/kg
(95% CL: 2500 - 4800 mg/kg), and for both sexes combined was 4000 mg/kg (95% CL: 3200 - 4600 mg/kg).The substance is not classified for acute oral toxicity according to EU criteria as the lowest LD50 is 3700 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
