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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

OECD Guideline 203, EU Method C1, no-GLP, key study, validity 2: 96h-LC50 = 24 mg/L.

Key value for chemical safety assessment

LC50 for freshwater fish:
24 mg/L

Additional information

Available data on short-term toxicity to fish

Four studies were recorded for the endpoint short-term toxicity to fish. An overview of this dataset is provided in the table below:

Method

Species

Basis for effect

Endpoint

Effect concentration

Reliability

Reference

OECD 203

EC Method C.1

Oncorhynchus mykiss

Mortality

96h-LC50

96h-NOEC

=24 mg/L (n)

=10 mg/L (n)

2

Wetton PM & Handley JW (1998)

OPTS EPA 560/6-002 (1982)

Pimephales promelas

Mortality

96h-LC50

96h-NOEC

=16 mg/L (n)

=7.8 mg/L (n)

2

Sousa JV & Holling JP (1984)

JIS K 0102-1986-71

Oryzias latipes

Mortality

48h-LC50 (10°C)

48h-LC50

(20°C)

48h-LC50

(30°C)

=44 mg/L (n)

=27 mg/L (n)

=6.8 mg/L (n)

2

Tsuji S et al (1986)

OECD 203

 

Pimephales promelas

Mortality

96h-LC50

=11.2 mg/L (m)

2

Geiger DL et al (1986)

n: nominal concentration - m: measured concentration

Sensitivity of fish to TBEP exposure

For the three species, the toxicity parameters (96h-LC50, 48h-LC50) were in the same order of magnitude ie from 10 mg/L to 100 mg/L. The short-term toxicity to fish of TBEP is increased by temperature (Tsuji et al., 1986) which is a conventional pattern.

Selection of the key study

The study of Wetton and Handley (1998) was flagged as key study for this endpoint.

Conclusion

Based on the available dataset, tris(2 -butoxyethyl) phosphate would be classified as harmful to freshwater fish in accordance with the classification system of EU (Directive 67/548/EC).