Registration Dossier

Toxicological information

Specific investigations: other studies

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Administrative data

Endpoint:
biochemical or cellular interactions
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Well-documented, but supplementary non-regulatory study

Data source

Reference
Reference Type:
publication
Title:
The effect of the plasticisers TBEP and DEHP on beta adrenergic ligand binding to alpha1-acid glycoprotein and mononuclear leucocytes
Author:
Sager G, Little C
Year:
1989
Bibliographic source:
Biochem. Pharmacol. 38(15): 2551 - 2557

Materials and methods

Test guideline
Qualifier:
no guideline required
GLP compliance:
no
Type of method:
in vitro

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Applicant's summary and conclusion

Conclusions:
TBEP may have pharmacodynamic as well as pharmacokinetic effects, by interacting with both specific and non-specific binding sites. This may be of concern due to its wide-spread use in soft plastics and synthetic rubber.