Registration Dossier
Registration Dossier
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EC number: 201-122-9 | CAS number: 78-51-3
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Well-documented, but supplementary non-regulatory study
Data source
Reference
- Reference Type:
- publication
- Title:
- The effect of the plasticisers TBEP and DEHP on beta adrenergic ligand binding to alpha1-acid glycoprotein and mononuclear leucocytes
- Author:
- Sager G, Little C
- Year:
- 1 989
- Bibliographic source:
- Biochem. Pharmacol. 38(15): 2551 - 2557
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- GLP compliance:
- no
- Type of method:
- in vitro
Test material
- Reference substance name:
- Tris(2-butoxyethyl) phosphate
- EC Number:
- 201-122-9
- EC Name:
- Tris(2-butoxyethyl) phosphate
- Cas Number:
- 78-51-3
- Molecular formula:
- C18H39O7P
- IUPAC Name:
- tris(2-butoxyethyl) phosphate
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- TBEP may have pharmacodynamic as well as pharmacokinetic effects, by interacting with both specific and non-specific binding sites. This may be of concern due to its wide-spread use in soft plastics and synthetic rubber.
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