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Ecotoxicological information

Long-term toxicity to aquatic invertebrates

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Description of key information

No long-term effects on reproduction of invertebrates are expected with the test substance Isopropyl laurate. 

Key value for chemical safety assessment

Additional information

There are no studies available on the long-term toxicity of Isopropyl laurate (CAS 10233-13-3) to aquatic invertebrates. The assessment was therefore based on a study conducted with the structurally most similar category member, for which data is available Isopropyl myristate (CAS 110-27-0), as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Further justification is given within the endpoint summary 6.1 and within the category justification section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was entered into IUCLID. Nevertheless, as can be seen in the data matrix of the category justification in Section 13, all reliable data in the category support the hazard assessment for this endpoint, by showing a consistent pattern of results.

In the selected read-across study, the chronic toxicity of Isopropyl myristrate (CAS 110-27-0) to Daphnia magna was tested according to OECD 202 (Scholz 1995) at 1 and 100 mg/L (nominal). After prolonged stirring, the test substance was filtered through glass fibre filter. No effects on mortality or reproduction were detected at both test substance concentrations. Therefore, the NOEC(21d) is >= 100 mg/L.

Thus, based on the above mentioned result, and due to the structural and profile similarities of the two substances, as are explained with in the overall endpoint summary 6.1 it can be concluded that no toxicological effects on aquatic invertebrates are expected up to the limit of water solubility for Isopropyl laurate (10233 -13 -3).