Registration Dossier
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EC number: 233-560-1 | CAS number: 10233-13-3
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No effects up the limit of water solubility
Key value for chemical safety assessment
Additional information
There are no studies available on the toxicity of Isopropyl laurate (CAS 10233-13-3) to algae. The assessment of isopropyl laurate was therefore based on studies conducted with the following structurally most similar category members, for which data is available Isopropyl myristate (CAS 110-27-0), Fatty acids, C16-C18 and C18 unsatd., branched and linear, Bu esters (CAS 163961-32-8) and Fatty acids, C16-18 and C18-unsatd., 2-ethylhexyl esters (CAS 85049-37-2), as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Further justification is given within the endpoint summary 6.1 and within the category justification section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was entered into IUCLID. Nevertheless, as can be seen in the data matrix of the category justification in Section 13, all reliable data in the category support the hazard assessment for this endpoint, by showing a consistent pattern of results.
In the key study, a read-across from the substance Isopropyl myristate (CAS 110-27-0), Desmodesmus subspicatus was tested according to EU Method C.3 and to GLP as a limit test (Rieche 1995). No effects on cell growth were stated at concentrations above the water solubility (ErC50 > 0.05 mg/L) in the filtered emulsion of the test medium, while presumably physical effects were observed in the emulsion without filtration (ErC50 < 100 mg/L, nominal).
In the supporting study, a read-across from Fatty acids, C16-C18 and C18 unsatd., branched and linear, Bu esters (CAS 163961-32-8), Desmodesmus subspicatus was tested under static conditions according to OECD 201 as limit test under GLP conditions (Hudson 2004). The tested concentration of 0.2 mg/L (nominal) was applied in a solvent-spike method (with acetone). The analytical measurement of the test substance resulted in an arithmetical mean of 0.054 mg/L, resulting in an EC50(72h) value of >0.054 mg/L and a NOEC(72h) of 0.054 mg/L, as no effect on cell growth was observed.
As another supporting study, a read across from, Fatty acids, C16-18 and C18-unsatd., 2-ethylhexyl esters (CAS 85049-37-2) was used. In this test, the marine alga Skeletonema costatum was tested with WAF according to ISO 10253. The resulting ErL50(72h) was determined as 281.4 mg/L (nominal) (Vryenhoef and McKenzie 2000).
Thus, based on the above mentioned result, and due to the structural and profile similarities of the substances, as are explained with in the overall endpoint summary 6.1 it can be concluded that no toxicological effects on algae are expected up to the limit of water solubility for Isopropyl laurate (CAS 10233 -13 -3).
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