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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
non-GLP study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1984
Report date:
1984

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Bismuth vanadium tetraoxide
EC Number:
237-898-0
EC Name:
Bismuth vanadium tetraoxide
Cas Number:
14059-33-7
Molecular formula:
Bi O4 V
IUPAC Name:
bismuth vanadium tetraoxide
Details on test material:
- Name of test material (as cited in study report): Sicopal-Gelb L-1110
- Physical state: solid
- Composition of test material, percentage of components: 57% BiVO4, 43% BiMoO6

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
CMC (carboxymethyl cellulose)
Details on oral exposure:
5 male and 5 female Wistar rats were given a single oral dose (5000 mg/kg bw) of the test substance in 0.5% CMC by gavage. The animals were ca. 12 weeks of age at the beginning of the study and were fasted 16 hours before dosing.
Doses:
5000 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Remarks on result:
other: no mortality occured
Mortality:
No mortality occured.
Clinical signs:
Clinical symptoms did not occur. Yellowish-green feces were noted during the study.
Body weight:
The animals had a starting mean body weight of 182 g (males) and 190 g (females). At the end of the study, the male animals had a mean body weight of 292 g, whereas the female animals exhibited a median body weight of 234 g.
Gross pathology:
Gross pathology did not reveal any lesions.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Under the conditions of this study, the LD50 following oral exposure was > 5000 mg/kg bw for male and female Wistar rats.