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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
non-GLP study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1982
Report date:
1982

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Bismuth vanadium tetraoxide
EC Number:
237-898-0
EC Name:
Bismuth vanadium tetraoxide
Cas Number:
14059-33-7
Molecular formula:
Bi O4 V
IUPAC Name:
bismuth vanadium tetraoxide
Details on test material:
- Name of test material (as cited in study report): Sicopal-Gelb L-1110
- Physical state: solid
- Composition of test material, percentage of components: 57% BiVO4, 43% BiMoO6

Test animals / tissue source

Species:
rabbit
Strain:
Vienna White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
yes, concurrent no treatment
Duration of treatment / exposure:
continuous
Observation period (in vivo):
8 days
Number of animals or in vitro replicates:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
cornea opacity score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
0
Reversibility:
fully reversible within: 8 days
Remarks on result:
no indication of irritation
Irritation parameter:
iris score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
0
Reversibility:
fully reversible within: 8 days
Remarks on result:
no indication of irritation
Irritation parameter:
conjunctivae score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
0
Reversibility:
fully reversible within: 8 days
Remarks on result:
no indication of irritation
Irritation parameter:
chemosis score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
0
Reversibility:
fully reversible within: 8 days
Remarks on result:
no indication of irritation

Any other information on results incl. tables

The mean scores calculated over all animals tested were 0 for corneal opacity, 0 for iris lesions, 0 for redness of the conjunctivae and 0 for edema formation.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Sicopal-Gelb is considered to be not irritating to the eye of white Vienna rabbits according to EU- and GHS-criteria under the conditions of the study.