Registration Dossier
Registration Dossier
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EC number: 247-852-1 | CAS number: 26628-22-8
Toxicity to birds
Administrative data
- Endpoint:
- short-term toxicity to birds: acute oral toxicity test
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one or more species of wild and domestic birds
- Author:
- Schafer EW Jr, Bowles WA Jr, Hurlbut J
- Year:
- 1 983
- Bibliographic source:
- PMID: 6882015, Arch Environ Contam Toxicol. 12(3):355-82
- Reference Type:
- review article or handbook
- Title:
- Sodium azide
- Author:
- Lewis RJ
- Bibliographic source:
- Sax's Dangerous Properties of Industrial Materials, 9th ed. 1996, 2947-8
- Reference Type:
- other: method describing paper
- Title:
- Susbstituted Phenyl N-Methylcarbamates as Temporary Immobilizing Agents for Birds
- Author:
- Schafer, EW, Starr RI, Cunningham DJ, Decino TJ
- Year:
- 1 967
- Bibliographic source:
- J Agric Food Chem 15(2): 287-9
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline Draft (Avian Repellency Test) (not officially approved)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 850.2100 (Avian Acute Oral Toxicity Test)
- GLP compliance:
- no
Test material
- Reference substance name:
- Sodium azide
- EC Number:
- 247-852-1
- EC Name:
- Sodium azide
- Cas Number:
- 26628-22-8
- Molecular formula:
- N3Na
- IUPAC Name:
- sodium azide
Constituent 1
- Dose method:
- gavage
- Analytical monitoring:
- not specified
- Vehicle:
- yes
Test organisms
- Test organisms (species):
- other: Agelaius phoeniceus
- Details on test organisms:
- TEST ORGANISM
- Common name: red-winged blackbird
- Source: wild-trapped
- Age at test initiation (mean and range, SD): no data
- Weight at test initiation (mean and range, SD): no data
- Sexes used: no data
- Cultural background:
- Disease free: no data
- Kept according to standard practices: yes
Study design
- Limit test:
- no
- Total exposure duration (if not single dose):
- 7 d
- Remarks:
- single treatment with 7d post-observation period
- Post exposure observation period:
- single treatment with 7d post-observation period
- No. of animals per sex per dose and/or stage:
- no data
- Control animals:
- not specified
- Nominal and measured doses / concentrations:
- no data
- Details on test conditions:
- ACCLIMATION
- Acclimation period: 2-6 weeks
- Acclimation conditions (same as test or not):same as test
- Feeding: ad libitum
- Health (any disease or mortality observed): not reported
- Fasting period before study: no data
FEED WITHHOLDING PERIOD BEFORE DOSING
- No. of days: no data
PEN SIZE AND CONSTRUCTION MATERIALS
- Description: no data
- Floor covering: no data
- Compliant to good husbandry practices: no
- Suitable to avoid crowding stress: yes
- Caging: individual
NO. OF BIRDS PER REPLICATE
- For negative control: no data
- For vehicle control: no data
- For treated: no data
NO. OF REPLICATES PER GROUP
- For negative control: no data
- For vehicle control: no data
- For treated: no data
Examinations
- Details on examinations and observations:
- Data recorded included affectation time, induction and duration of immobilization, mortality, regurgitation, weight gain or loss, and any unique physiological effects exhibited by the birds.
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 23.7 mg/kg bw
- Basis for effect:
- mortality
- Repellency factors (if applicable):
- R50 = 76.9 mg/kg
Applicant's summary and conclusion
- Conclusions:
- The LD50 (oral, red-winged blackbird) is 23.7 mg/kg.
- Executive summary:
The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one or more of 68 species of wild and domestic birds was determined by standardized testing procedures. Redwinged blackbirds were the most sensitive of the bird species tested on a large number of chemicals.
The LD50 (oral) for the toxicity of sodium azide to red-winged blackbird (Agelaius phoeniceus) was reported to be 23.7 mg/kg bw.
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