Registration Dossier
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EC number: 247-852-1 | CAS number: 26628-22-8
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Sodium azide
- Author:
- ACGIH (American Conference of Governmental Industrial Hygienists)
- Year:
- 1 991
- Bibliographic source:
- ISBN-13: 978-0936712963, Documentation of the Threshold Limit Values & Biological Exposure Indices, 6th ed, 1403-7
- Reference Type:
- publication
- Title:
- Brain metabolism in vivo. II. The distribution of lesions caused by azide, malononitrile, plasmocid and dinitrophenol poisoning in rats.
- Author:
- Hicks S.P.
- Year:
- 1 950
- Bibliographic source:
- AMA Arch Pathol. 50(5):545-61.
Materials and methods
Test material
- Reference substance name:
- Sodium azide
- EC Number:
- 247-852-1
- EC Name:
- Sodium azide
- Cas Number:
- 26628-22-8
- Molecular formula:
- N3Na
- IUPAC Name:
- sodium azide
Constituent 1
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- For more details see "details on results" section below
- Mortality:
- mortality observed, treatment-related
- Description (incidence):
- For more details see "details on results" section below
- Gross pathological findings:
- no effects observed
- Neuropathological findings:
- effects observed, treatment-related
- Description (incidence and severity):
- For more details see "details on results" section below
- Details on results:
- Repeated i.p. injections in rats of 5-10 mg/kg resulted in severe intoxication, with survivors showing demyelination of the nerve fibres of the CNS but no damage to the liver or kidney.
Applicant's summary and conclusion
- Conclusions:
- Repeated i.p. injections in rats of 5-10 mg/kg resulted in severe intoxication, with survivors showing demyelination of the nerve fibres of the CNS but no damage to the liver or kidney.
- Executive summary:
In a study cited from Hicks S.P. (1950), repeated i.p. injections in rats of 5-10 mg/kg resulted in severe intoxication, with survivors showing demyelination of the nerve fibres of the CNS but no damage to the liver or kidney.
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