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Toxicological information

Neurotoxicity

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Administrative data

Endpoint:
neurotoxicity
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Referenceopen allclose all

Reference Type:
review article or handbook
Title:
Sodium azide
Author:
ACGIH (American Conference of Governmental Industrial Hygienists)
Year:
1991
Bibliographic source:
ISBN-13: 978-0936712963, Documentation of the Threshold Limit Values & Biological Exposure Indices, 6th ed, 1403-7
Reference Type:
publication
Title:
Brain metabolism in vivo. II. The distribution of lesions caused by azide, malononitrile, plasmocid and dinitrophenol poisoning in rats.
Author:
Hicks S.P.
Year:
1950
Bibliographic source:
AMA Arch Pathol. 50(5):545-61.

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium azide
EC Number:
247-852-1
EC Name:
Sodium azide
Cas Number:
26628-22-8
Molecular formula:
N3Na
IUPAC Name:
sodium azide

Results and discussion

Results of examinations

Clinical signs:
effects observed, treatment-related
Description (incidence and severity):
For more details see "details on results" section below
Mortality:
mortality observed, treatment-related
Description (incidence):
For more details see "details on results" section below
Gross pathological findings:
no effects observed
Neuropathological findings:
effects observed, treatment-related
Description (incidence and severity):
For more details see "details on results" section below
Details on results:
Repeated i.p. injections in rats of 5-10 mg/kg resulted in severe intoxication, with survivors showing demyelination of the nerve fibres of the CNS but no damage to the liver or kidney.

Applicant's summary and conclusion

Conclusions:
Repeated i.p. injections in rats of 5-10 mg/kg resulted in severe intoxication, with survivors showing demyelination of the nerve fibres of the CNS but no damage to the liver or kidney.
Executive summary:

In a study cited from Hicks S.P. (1950), repeated i.p. injections in rats of 5-10 mg/kg resulted in severe intoxication, with survivors showing demyelination of the nerve fibres of the CNS but no damage to the liver or kidney.