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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Unsuitable test system

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Unnamed
Year:
1985
Reference Type:
review article or handbook
Title:
Recommendation from the Scientific Committee on Occupational Exposure Limits (SCOEL) for Sodium Azide
Year:
2008
Bibliographic source:
European Commission: Scientific Committee on Occupational Exposure Limits (SCOEL)

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: OECD guideline 404 (acute dermal irritation/corrosion)
Deviations:
yes
Remarks:
1 and 4h exposure
GLP compliance:
not specified
Test type:
fixed dose procedure

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium azide
EC Number:
247-852-1
EC Name:
Sodium azide
Cas Number:
26628-22-8
Molecular formula:
N3Na
IUPAC Name:
sodium azide

Test animals

Species:
rabbit
Strain:
other: New Zealand, unspecified
Sex:
male/female

Administration / exposure

Type of coverage:
other: semi-occlusive & occlusive
Vehicle:
unchanged (no vehicle)
Duration of exposure:
4 h
Doses:
0.5 g
No. of animals per sex per dose:
6 animals per dose
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
>= 500 - <= 1 000 mg/kg bw
Remarks on result:
other: Estimation from given data (animal weight 2-4kg, applicated dose 4 x 0.5g per animal)
Mortality:
3 animals were found dead after 1 hour exposure
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data

Applicant's summary and conclusion

Interpretation of results:
Category 3 based on GHS criteria
Conclusions:
In a dermal irritation study according to OECD 404, three of six animals exposed to 4 x 0.5 g of Sodium azide died 1 h / 4 h treatment. As the weight of the rabbits was 2-4 kg, the LD50(rabbit, dermal) can be estimated to range between 500 - 1000 mg/kg bw.
Executive summary:

Using a defined method for the determination of irritant and corrosive effects (OECD 404, 1981), the effects of varying the exposure time and the extent of occlusion were investigated and compared in rabbit skin experiments (by occlusive and semi-occlusive methods, each at exposure times of 1 hr and 4 hr). Results showed that, independent from treatment, three of six animals of each group were found dead after dermal exposure to 4 x 0.5g of sodium azide. As the weight of the rabbits was 2-4 kg, the LD50(rabbit, dermal) can be estimated to range between 500 - 1000 mg/kg bw.

The benchmarks for toxicity categorization according to GHS are acute toxicity estimates (LD50) of 201-1000 (toxicity category III) which is covered by the estimated LD50.