Sodium azide

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

unsuitable test system

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Unnamed

Year:

1985

Reference 2

Reference Type:

review article or handbook

Title:

Recommendation from the Scientific Committee on Occupational Exposure Limits (SCOEL) for Sodium Azide

Author:

Anonymous

Year:

2008

Bibliographic source:

European Commission: Scientific Committee on Occupational Exposure Limits (SCOEL)

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: OECD guideline 404 (acute dermal irritation/corrosion)

Deviations:

yes

Remarks:

1 and 4h exposure

GLP compliance:

not specified

Test type:

fixed dose procedure

Test material

Test material information

Constituent 1

Reference substance name:

Sodium azide

EC Number:

247-852-1

EC Name:

Sodium azide

Cas Number:

26628-22-8

Molecular formula:

N3Na

IUPAC Name:

sodium azide

Test animals

Species:

rabbit

Strain:

other: New Zealand, unspecified

Sex:

male/female

Administration / exposure

Type of coverage:

other: semi-occlusive & occlusive

Vehicle:

unchanged (no vehicle)

Duration of exposure:

4 h

Doses:

0.5 g

No. of animals per sex per dose:

6 animals per dose

Control animals:

not specified

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

>= 500 - <= 1 000 mg/kg bw

Remarks on result:

other: Estimation from given data (animal weight 2-4kg, applicated dose 4 x 0.5g per animal)

Mortality:

3 animals were found dead after 1 hour exposure

Clinical signs:

other: no data

Gross pathology:

no data

Applicant's summary and conclusion

Interpretation of results:

Category 3 based on GHS criteria

Conclusions:

In a dermal irritation study according to OECD 404, three of six animals exposed to 4 x 0.5 g of sodium azide died 1 h / 4 h treatment. As the weight of the rabbits was 2-4 kg, the LD50 (rabbit, dermal) can be estimated to range between 500 - 1000 mg/kg bw.

Executive summary:

In a defined method for the determination of irritant and corrosive effects (OECD 404, 1981), the effects of varying the exposure time and the extent of occlusion were investigated and compared in rabbit skin experiments (by occlusive and semi-occlusive methods, each at exposure times of 1 hr and 4 hr). Results showed that, independent from treatment, three of six animals of each group were found dead after dermal exposure to 4 x 0.5g of sodium azide. As the weight of the rabbits was 2-4 kg, the LD50 (rabbit, dermal) can be estimated to range between 500 - 1000 mg/kg bw. The benchmarks for toxicity categorization according to GHS are acute toxicity estimates (LD50) of 200-1000 (toxicity category III) which is covered by the estimated LD50.