Registration Dossier
Registration Dossier
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EC number: 247-852-1 | CAS number: 26628-22-8
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Effect of sodium azide on in vitro embryo development in the mouse
- Author:
- Robertson J.L., Roudebush W.E.
- Year:
- 1 992
- Bibliographic source:
- Proc. 25th annual meeting of the society for the study of reproduction, p122, #287.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- - Principle of test:
The objective of this study was to determine the toxicity potential of sodium azide on muse embryo development in vitro.
- GLP compliance:
- no
- Type of method:
- in vitro
Test material
- Reference substance name:
- Sodium azide
- EC Number:
- 247-852-1
- EC Name:
- Sodium azide
- Cas Number:
- 26628-22-8
- Molecular formula:
- N3Na
- IUPAC Name:
- sodium azide
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- Pronuclear mouse embryos
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- Sodium azide has a drastically toxic effect on the in vitro growth of mouse embryos at concentrations of 10^(-4) mol/L in the petri dish or greater.
- Executive summary:
The toxicity potential of sodium azide on mouse development was determined in vitro. Embryos were treated with sodium azide and evaluated following 72 hours of culture. The results show that sodium azide has a drastically toxic effect on the in vitro growth of mouse embryos at concentrations of 10 -4 mol/L in the petri dish or greater. It was toxic to most, though not all, mouse embryos at 10 -5 mol/L but was not significantly toxic at levels of 10 -6 mol/L or less.
The study does not follow any guideline and is not GLP compliant. Moreover, further details are not available for this study and documentaion is insufficient for assessment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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