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EC number: 915-179-9 | CAS number: -
The acute toxicity ofKH2PO3/K2HPO3was investigated following a single oral administration to the Sprague Dawley rat followed by a 14-day observation period.
A sub-group of 1 female animal was initially dosed at 5000 mg/kg (Step 1). Mortality occurred on Day 2 following dosing. Clinical signs observed prior to death were limited to piloerection and reduced activity.
No mortality occurred and no clinical signs were seen in the 2 sub-groups of animals subsequently dosed at 2000 mg/kg (Steps 2 and 3).
Body weight changes recorded during the study were within the expected range for this strain and age of animals.
No abnormalities were observed at necropsy examination performed in the early decedent animal or in those sacrificed at the end of the observation period.
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