Registration Dossier

Diss Factsheets

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

A GLP MITI study assessing the bioaccumultion in Cyprinus carpio and a well documented Catabol QSAR prediction of the BCF for all isomers using analogues for validation is available.

Key value for chemical safety assessment

BCF (aquatic species):
320 L/kg ww

Additional information

The bioconcentration factor in Cyprinus carpio was 229-433 and 206-415 at 2.5 and 25 ug/L, respectively. The mid-point of these measured values (320 L/kg wet wt.) is used to represent BCF of the substance components in the chemical safety assessment.


The bioconcentration potential (bioconcentration factor, BCF) of the four major constituents in divinylbenzene (DVB-55) have been assessed using a quantitative structure-activity relationship (QSAR) model (BCF baseline model v.02.06) as described by Dimitrov et al (2005) and implemented in OASIS CATALOGIC v 5.11.12. Constituents of DVB-55 are not bioaccumulative with high , as BCF values range from 219 and 302 L/kg.


The QSAR predictions are within the same range, as measured in Carp, which is chosen as a key value for the chemical safety assessment.