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Ecotoxicological information

Short-term toxicity to fish

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Description of key information

Several GLP and non-GLP studies according to or similar to OECD guidelines 203 are available for the reaction mass of divinylbenzene and ethylstyrene. In addition, one GLP study according to OECD guideline 204 is available.
The 14-day LC50 for DVB-HP grade (reaction mass of 80% divinylbenzene and 20% ethylstyrene) was 1.78 mg/L in medaka.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
1.78 mg/L

Additional information

A total of six acute toxicity studies with fish exist for the reaction mass of divinylbenzene and ethylstyrene. Two acute fish toxicity studies (non-GLP, similar to OECD guideline 203) were performed with DVB-55 (reaction mass of approximately 55% divinylbenzene and 45% ethylstyrene). The other four acute toxicity test were performed with DVB-HP (reaction mass of approximately 80% divinylbenzene and 20% ethylstyrene). The two key studies for DVB-HP were conducted under GLP and according to OECD guidelines 203 and 204.

The DVB-HP grade proved to be more toxic to fish (and also invertebrates) in comparison to DVB-55. The 96 hour LC50 for DVB-55 was 7.5 mg/L in fathead minnows, while the 96 hour LC50 for DVB-HP ranged from 3.45 - 4.16 mg/L in medaka fish. In a high quality study with medaka fish, the 14 -day NOEC and LC50 for DVB-HP was determined to be 0.456 and 1.78 mg/L, respectively. The 14 -day LC50 of 1.78 mg/L was the lowest acute endpoint, and this value was selected as the key parameter for short-term toxicity to fish.

No acute toxicity study in fish is available for DVB-63 (reaction mass of approximately 63% divinylbenzene and 37% ethylstyrene). However, as higher concentrations of each of the components are present in the grades tested (DVB-55 and DVB-HP), the toxicity of both components of this reaction mass has been sufficiently investigated by the studies conducted on those grades.