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EC number: 910-757-7 | CAS number: -
- Life Cycle description
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Endpoint summary
Administrative data
Description of key information
A GLP-study according to OECD guideline 401 is available for DVB-96. In addition two non-GLP studies equivalent to OECD guideline 401 are available for DVB-HP and DVB-55. Two non-GLP studies equivalent or similar to OECD guideline 403 and one non-GLP study equivalent to OECD guideline 402 are available for DVB-55.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 17 600 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 8 000 mg/kg bw
Additional information
The oral LD50 values for different grades of the reaction mass of divinylbenzene and ethylstyrene in rats ranges from >2000 to 4100 mg/kg. The grades tested cover the highest concentration of divinylbenzene (DVB-96: 96% divinylbenzene and 4% ethylstyrene) and ethylstyrene (DVB-55: 55% divinylbenzene and 45% ethylstyrene). All oral LD50s were greater than 2000 mg/kg.
Both acute inhalation studies available for DVB-55 were conducted equivalent or similar to OECD guideline 403 with some deviations regarding the exposure duration and temperature of the vapor. In one study the highest dose tested was 5 mg/l which did not lead to any mortality in rats. However, in mice an LC50 between 0.8 and 2.3 mg/l can be estimated from that study.
In a second study DVB-55 concentrations up to 17.6 mg/l administered over 7 hours at 80°C did not cause any mortality in male rats, whereas 25.7 mg/l administered over 7 hours at 100°C killed 3 of 5 male rats. One of 5 female rats died after 2 hours exposure to 144 mg/l DVB-55 at 130°C. Based on the available data and considering the exposure conditions (duration and temperature), there is no clear evidence that the LC50 would be smaller than 20 mg/l under normal conditions. The LC50 in rats is greater than 17.6 mg/l.
A dermal LD50 of 8000 mg/kg bw was established for DVB-55 in a non-GLP study equivalent to OECD guideline 402. This is the only grade of this reaction mass which was tested for acute toxicity via the dermal route. However, DVB-55 contains both components of the reaction mass at equivalent concentrations. Based on the high LD50 for the reaction mass of 55% divinylbenzene and 45% ethylstyrene, it can be concluded that the other grades of the reaction mass (DVB-63 and DVB-HP), containing up to 80% divinylbenzene, are not acutely harmful via the dermal route.
Justification for classification or non-classification
LD50 values for oral and dermal route are greater than 2000 mg/kg/bw and the LC50 value is greater than 17.6 mg/l with no clear evidence for an LC50 value < 20 mg/l. According to the EU criteria for classification and labeling, the reaction mass of divinylbenzene and ethylstyrene is not classified for acute toxicity for any route of exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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