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EC number: 910-757-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1984
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- The study was not conducted according to guideline/s and GLP but the report contains sufficient data for interpretation of study results
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- GLP compliance:
- no
- Test type:
- other: Standard acute method except the exposure duration was 6 hours, instead of the typical 4 hour exposure period used for acute studies, because this study was intended to help set dose levels for a 2-week inhalation study..
- Limit test:
- yes
Test material
- Reference substance name:
- Reaction mass of divinylbenzene and ethylstyrene
- EC Number:
- 910-757-7
- Cas Number:
- N/A
- Molecular formula:
- Divinylbenzene: C10H10 Ethylstyrene: C10H12
- IUPAC Name:
- Reaction mass of divinylbenzene and ethylstyrene
- Details on test material:
- Divinylbenzene 55 ( lot #840329-007) was obtained from The Dow Chemical Company production facilities, Midland, MI.
Capillary gas chromatographic analysis o f the test material revealed that 96.6% was composed of the following four compounds:
meta-divinylbenzene 38.3%
para-divinylbenzene 15.4%
meta-ethylvinyl benzene 31.5%
para-ethylvinylbenzene 11.2%
Constituent 1
Test animals
- Species:
- other: rat and mice
- Strain:
- other: Fischer 344 rats and B6C3F1 mice
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Male and female Fischer 344 (F-344) rats (4-weeks of age) and B6C3F1 mice ( 7 weeks of age) were obtained from Charles River Breeding Laboratories Inc., Kingston, NY and Portage, M I , respectively. All animals were 9-10 weeks of age when exposed to DVB-55. Animals were fed Certified Rodent Chow (Purina Co., St. Louis, MO) and water ad libitum except during exposure.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- The test material was vapourized by metering DVB-55 at a constant rate into a glass J-tube. Heated compressed air passed through the J-tube to volatize the test material prior to entering the chamber. The compressed air was heated with a flameless heat torch (Master FHT-4) to the minimum extent necessary (70-90°C) to completely vapourize the test material. The nominal concentration (ratio of the amount of test material to vapourized to the total amount of air flowing through the chamber) was calculated for each exposure period.
Stainless and glass 157L Rochester-type chambers were used for this study. The chamber airflow was maintained at 30 L/inin. The minimum and maxinium chamber temperature for the 4 exposures ranged from 70-80°F and the relative humidity for the 4 exposures ranged from 34-62%. - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 6 h
- Concentrations:
- Rats - 0 or 5.0 mg/L
Mice - 0, 0.8, 2.3 or 5.0 mg/L - No. of animals per sex per dose:
- 5/sex/dose
- Control animals:
- yes
- Details on study design:
- Animals were weighed and examined prior to exposure to the test material. Animals were observed during the exposure period and at least daily during the two-week post-exposure period for any exposure related effects. All surviving rats were weighed on the first day after exposure and approximately twice per week during the two-week post-exposure period.
- Statistics:
- None
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 5 mg/L air (nominal)
- Exp. duration:
- 6 h
- Remarks on result:
- other: rats
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- 0.8 mg/L air (nominal)
- Exp. duration:
- 6 h
- Remarks on result:
- other: mice
- Sex:
- male/female
- Dose descriptor:
- LC100
- Effect level:
- 2.3 mg/L air (nominal)
- Exp. duration:
- 6 h
- Remarks on result:
- other: mice
- Mortality:
- Rats: no mortality
Mice: 5 mg/L- 5/5 male and female mice died, 2.3 mg/L- 5/5 males died and 4/5 females died, 0.8 mg/L and controls - no deaths - Clinical signs:
- other: Rats (5 mg/L) appeared to be sedated during exposure and had a reddish material around the face (up to 2 days) Mice sedated at ≥2.3 mg/L during exposure and (0.8 mg/L) slightly lethargic at the end of the 6-hr exposure period
- Body weight:
- In rats, a slight body weight loss was observed following exposure to DVB-55. Two weeks after exposure to DVB-55, the animal weights were comparable to control values.
Mice exposed to 0.8 mg/L DVB-55 had a greater body weight loss (approximately 10%) than control animals immediately after the exposure period. These mice quickly recovered and their body weights were comparable to control values within 2 weeks. No other effects were observed in these animals which were considered to be exposure related. - Gross pathology:
- None
- Other findings:
- None
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LC50 in rats is greater than 5 mg/L (highest concentration tested in this study).
- Executive summary:
Groups of 5 male and 5 female rats were exposed for 6 hours to 0 or 5.0 mg/L divinylbenzene 55 (DVB-55); groups of 5 male and 5 female mice were exposed for the same time period to 0, 0.8, 2.3 or 5.0 mg/L DVB-55.
Exposure of rats to 5 mg/L of DVB-55 resulted in sedation during the exposure period with a reddish material around the face for at most 2 days following the exposure period. A slight body weight loss was observed following exposure to DVB-55. Two weeks after exposure to DVB-55, the animal weights were comparable to control values.
Mice exposed to 5 mg/L DVB-55 were sedated like the rats but died several hours after the exposure terminated. Similarly, mice exposed to 2.3 mg/L were sedated with 9 out of 10 dying shortly after the exposure terminated. Mice exposed to 0.8 mg/L DVB-55 were slightly lethargic at the end of the 6-hr exposure period and had a greater body weight loss than control animals immediately after the exposure period. These mice quickly recovered and were comparable to control values within 2 weeks. No other effects were observed in these animals which were considered to be exposure related.
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