Registration Dossier
Registration Dossier
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EC number: 278-758-9 | CAS number: 77745-66-5
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2010
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- yes
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Triisotridecyl phosphite
- EC Number:
- 278-758-9
- EC Name:
- Triisotridecyl phosphite
- Cas Number:
- 77745-66-5
- Molecular formula:
- C39H81O3P
- IUPAC Name:
- tris(2-methylnonacosyl) phosphite
Constituent 1
In vivo test system
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
Study design: in vivo (LLNA)
- Vehicle:
- acetone/olive oil (4:1 v/v)
- Concentration:
- 25%, 50%, 100%
- No. of animals per dose:
- 3
- Statistics:
- EC3= 92.1%
Results and discussion
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Value:
- 1.25
- Test group / Remarks:
- 25% concentration
- Parameter:
- SI
- Value:
- 2.31
- Test group / Remarks:
- 50% concentration
- Parameter:
- SI
- Value:
- 3.13
- Test group / Remarks:
- 100% concentration
Any other information on results incl. tables
Concentration |
dpm/node |
Test / Control Ratio |
Vehicle (acetone/olive oil 4:1) |
756.88 |
N/A |
25% |
942.43 |
1.25 |
50% |
1746.07 |
2.31 |
100% |
2367.08 |
3.13 |
EC3= 92.1% |
||
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated informationweak
- Conclusions:
- Test substance was only postive (ratio >3) at a concentration of 100%, with an EC3 of 92.1%. While this substance is classifiable as a skin sensitiser based on these results, it would only be a weak sensitiser.
- Executive summary:
TiTDP was test using the LLNA assay at concentrations of 25%, 50%, and 100%. It was only just barely positive at the 100% concentration. The calculated EC3 value is 92.1%. The results suggest that while TiTDP will be classified as a skin sensitiser (since there is only one category for skin sensitisers) it is expected to be only a weak skin sensitiser.
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