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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

Description of key information

Toxicity to microorganisms: 3hr EC50 >100 mg/l (activated sludge respiration inhibition, OECD 209), read-across from an analogous substance.

Key value for chemical safety assessment

Additional information

There are no reliable microorganism toxicity data available for tetrapropyl orthosilicate, therefore good quality data for the analogous substance, tetraethyl orthosilicate (CAS 78 -10 -4), have been read across. Both substances share the same hydrolysis product, silicic acid

; the other hydrolysis products being propanol and ethanol, respectively. Propanol and ethanol do not have adverse effects on microorganisms.

Both tetrapropyl orthosilicate and tetraethyl orthosilicate are within an analogue group of substances that exhibit no evidence of significant toxicity to microorganisms

It is therefore considered valid to read-across the results for tetraethyl orthosilicate to fill the data gap for the registered substance.Additional information is given in a supporting report (PFA, 2013j) attached in Section 13 of the IUCLID 5 dossier.

A 3hr EC50value of >100 mg/l (nominal) was determined for tetraethyl orthosilicate.

The study is considered to be reliability 1 (reliable without restrictions); the read across of the result is considered to be reliability 2 (reliable with restrictions).