Octadecan-1-ol, ethoxylated

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

Nov 1975

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1975

Report date:

1975

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

limited reporting, no details on animals and animal accomodation and test procedure; no body weights recorded, no gross macroscopic examination performed, clinical signs of toxicity not reported

GLP compliance:

no

Remarks:

Prior to implementation of GLP.

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Octadecan-1-ol, ethoxylated

EC Number:

500-017-8

EC Name:

Octadecan-1-ol, ethoxylated

Cas Number:

9005-00-9

Molecular formula:

not applicable, UVCB

IUPAC Name:

2-octadecoxyethanol

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Age at study initiation: young adults
- Weight at study initiation: 200 - 300 g
- Fasting period before study: The animals were fasted for 24 h prior to dose administration
- Housing: in mesh buttom cages
- Diet: ad libitum
- Water: ad libitum

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

2.5, 5, 10, 20 and 40 g/kg bw

No. of animals per sex per dose:

3 males and 2 females

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations: The animals were observed daily.
- Necropsy of survivors performed: no

Statistics:

The LD50 was calculated according to the method of Miller and Tainter (Proc. Soc. Biol. Med. 57, 261 (1944)).

Results and discussion

Effect levels

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 21 000 mg/kg bw

Based on:

test mat.

Mortality:

At 20 g/kg bw, 2/5 animals died on study Days 1 and 6.
At 40 g/kg bw, 5/5 animals died on the day of dosing.

Clinical signs:

other: other: No data.

Gross pathology:

No data.

Applicant's summary and conclusion

Interpretation of results:

other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No. 1272/2008.

Conclusions:

For the test substance a LD50 (rat, m/f) > 21000 mg/kg bw was determined in a study according to OECD guideline 401.