Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Toxicity to reproduction

Currently viewing:

Administrative data

Endpoint:
screening for reproductive / developmental toxicity
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Justification for type of information:
Please refer to the category justification provided in the category object.

Data source

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Octadecan-1-ol, ethoxylated
EC Number:
500-017-8
EC Name:
Octadecan-1-ol, ethoxylated
Cas Number:
9005-00-9
Molecular formula:
not applicable, UVCB
IUPAC Name:
2-octadecoxyethanol

Results and discussion

Results: P0 (first parental generation)

Effect levels (P0)

Key result
Dose descriptor:
NOAEL
Effect level:
>= 1 000 mg/kg bw/day (actual dose received)
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other: No toxicologically relevant effects observed

Target system / organ toxicity (P0)

Key result
Critical effects observed:
no

Results: F1 generation

Effect levels (F1)

Key result
Dose descriptor:
NOAEL
Generation:
F1
Effect level:
>= 1 000 mg/kg bw/day (actual dose received)
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other: No toxicologically relevant effects observed

Target system / organ toxicity (F1)

Key result
Critical effects observed:
no

Overall reproductive toxicity

Key result
Reproductive effects observed:
no

Any other information on results incl. tables

For a detailed assessment of the reproductive / developmental toxicity of the Alcohol Ethoxylates (AE) category, please refer to the category justification attached to the category object.

Applicant's summary and conclusion

Conclusions:
Applying read-across based on grouping of substances (category approach), no toxicologically relevant effects in relation to reproductive / developmental toxicity and a NOAEL for reproductive toxicity ≥ 1000 mg/kg bw/day are predicted for the registered substance.
Executive summary:

The available data on reproductive / developmental toxicity in the 'linear' subgroup of the Alcohol Ethoxylates (AE) category indicate no toxicologically relevant effects for the registered substance. As explained in the category justification, the differences in molecular structure and composition between the registered substance and the members of the AE category are unlikely to lead to differences with respect to reproductive / developmental toxicity.