Registration Dossier
Registration Dossier
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EC number: 283-464-9 | CAS number: 84649-84-3
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation in aquatic species: fish
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance has a low potential for bioaccumulation based on log Kow <=3 and a low potential to cross biological membranes
- Justification for type of information:
- For the determination of the BCF fish of cationic surfactants classical test methods like OECD 305 are not suitable as the test substance sorbs to negatively charged surfaces like glass and fish leading to incorrect results. Therefore modeling is currently the most reliable approach to estimate the bioaccumulation potential. The Arnot & Gobas Model (2003) for the estimation of the BCF fish takes into adsorption, distribution, metabolism and excretion (ADME) of a substance in fish. This model is included in the US EPA Estimation program BCF BAF Version 3.01. The highest estimated BCF fish for DMAs is 223 which is well below the B criteria for the PBT / vPvB Assessment. This value may be used for the assessment of secondary poisioning. This modelling approach is explained in detail in the IUCLID 'Endpoint summary Bioaccumulation'.
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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