Registration Dossier
Registration Dossier
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EC number: 214-604-9 | CAS number: 1163-19-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study performed prior to international guidelines and GLPs
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Toxicological and environmental factors involved in the selection of decabromodiphenyl oxide as a fire retardant chemica
- Author:
- Norris et al
- Year:
- 1 974
- Bibliographic source:
- JFF/Combustion Toxicology 1, 52-77.
- Reference Type:
- publication
- Title:
- Toxicological and environmental factors involved in the selection of decabromodiphenyl oxide as a fire retardant chemical,
- Author:
- Norris et al.
- Year:
- 1 973
- Bibliographic source:
- Applied Polymer Symposia. No.22. Polymeric Materials for Unusual Service Conditions. 195-219.
- Reference Type:
- publication
- Title:
- Toxicology and human health assessment of decabromodiphenyl ether
- Author:
- Hardy et al.
- Year:
- 2 009
- Bibliographic source:
- Critical Reviews in Toxicology 39(S3): 1-44.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- see below
- GLP compliance:
- no
Test material
- Reference substance name:
- Bis(pentabromophenyl) ether
- EC Number:
- 214-604-9
- EC Name:
- Bis(pentabromophenyl) ether
- Cas Number:
- 1163-19-5
- Molecular formula:
- C12Br10O
- IUPAC Name:
- bis(pentabromophenyl) ether
- Details on test material:
- Former commercial product FR BA-300 used. Composed of 77% BDE 209, 22% nonaBDEs and 0.8% octaBDEs.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: shaved, with or with abrasion
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Duration of treatment / exposure:
- see below
- Observation period:
- see below
- Number of animals:
- see below
Results and discussion
Any other information on results incl. tables
see below
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Not irritating.
- Executive summary:
Norris et al. (1973, 1974) reported that FR-300-BA applied as dry solid on shaved skin of New Zealand albino rabbits caused essentially no response on intact skin and a slight erythematous and edematous response on abraded skin after a single exposure of 24 h. Repeated exposures to intact skin for 5 days/week for 2 weeks and to abraded skin for 3 days did not alter the responses observed following a single administration.
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