Cetrimonium chloride

Solubility in organic solvents / fat solubility

Link to relevant study record(s)

Reference

Endpoint:

solubility in organic solvents / fat solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2012

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Qualifier:

equivalent or similar to guideline

Guideline:

other: Screening test is similar to the preliminary test in OECD guideline for the testing of chemicals, No. 105, Water Solubility

Principles of method if other than guideline:

The solubility of the test substance is investigated in a combined screening test (which is similar to OECD TG 105) followed by LCMS analysis of solutions obtained in the screening test.

Key result

Medium:

n-octanol

Solubility:

290 g/L

Temp.:

23 °C

Remarks on result:

other: analysed using LCMS

Details on results:

Another fraction of the test sample resulted in lower octanol solubility of 200 g/L. This lower result was considered to be due to lack of the test substance.

Conclusions:

Under the study conditions, the octanol solubility of the test substance was determined to be 290 g/L at 23°C (Farnback, 2012).

Executive summary:

A study was conducted to determine the n-octanol solubility of the test substance, C16 TMAC (Purity: 95.6%) in a combined screening test using the slow stirring method and LCMS analysis, according to a method similar to OECD Guideline 105. Under the study conditions, the octanol solubility of the test substance was determined to be 290 g/L at 23°C (Farnback, 2012).

Description of key information

The solubility of the test substance in organic solvents was determined using the slow stirring method and LCMS analysis, according to a method that is similar to OECD Guideline 105 (Farnback, 2012).

Additional information

290 g/L at 23°C