Registration Dossier
Registration Dossier
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EC number: 203-928-6 | CAS number: 112-02-7
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Screening test is similar to the preliminary test in OECD guideline for the testing of chemicals, No. 105, Water Solubility
- Principles of method if other than guideline:
- The solubility of the test substance is investigated in a combined screening test (which is similar to OECD TG 105) followed by LCMS analysis of solutions obtained in the screening test.
- Key result
- Medium:
- n-octanol
- Solubility:
- 290 g/L
- Temp.:
- 23 °C
- Remarks on result:
- other: analysed using LCMS
- Details on results:
- Another fraction of the test sample resulted in lower octanol solubility of 200 g/L. This lower result was considered to be due to lack of the test substance.
- Conclusions:
- Under the study conditions, the octanol solubility of the test substance was determined to be 290 g/L at 23°C (Farnback, 2012).
- Executive summary:
A study was conducted to determine the n-octanol solubility of the test substance, C16 TMAC (Purity: 95.6%) in a combined screening test using the slow stirring method and LCMS analysis, according to a method similar to OECD Guideline 105. Under the study conditions, the octanol solubility of the test substance was determined to be 290 g/L at 23°C (Farnback, 2012).
Reference
Description of key information
The solubility of the test substance in organic solvents was determined using the slow stirring method and LCMS analysis, according to a method that is similar to OECD Guideline 105 (Farnback, 2012).
Key value for chemical safety assessment
Additional information
290 g/L at 23°C
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