Registration Dossier

Physical & Chemical properties

Endpoint summary

Administrative data

Description of key information

Additional information

Appearance/physical state/colour

The substance is a clear, colourless to slightly yellow, viscous liquid. It is practically odourless, slightly hygroscopic and may crystallize on prolonged storage.


Melting point/freezing point

The freezing point of D-Panthenol was determined to be -25.0 °C, which is equal to 248.2 K.


Boiling point

The boiling point of D-Panthenol was determined to be 235.6 °C which is equal to 508.8 K using thermal analysis (DSC). The atmospheric pressure during the measurements was 99.5 kPa.



The density of the substance was 1.200 g/cm³ at 20 °C.


Particle size distribution (Granulometry)

In accordance with REACH Regulation 1907/2006/EC Annex VII column 2, assessment of particle size distribution can be waived as the substance is a liquid.


Vapour pressure

The vapor pressure of D-Panthenol was measured at test temperatures of 70 °C, 80 °C and 90 °C and was determined to be 1.7E-01 Pa at 70 °C, 1.3 Pa at 80 °C, 3.9 Pa at 90 °C. The vapor pressure of D-Panthenol at 25 °C was extrapolated from the vapor pressure curve and was calculated to be 5.6E-05 Pa at 25 °C.


Partition coefficient

The n-Octanol / water partition coefficient (logPow) of D-Panthenol was determined by the shake flask method to be -1.06 (± 0.03) at 22 °C. The pH in the aqueous phase was 8.0.


Water solubility

The water solubility of D-Panthenol was determined using a simplified flask method and was found to be > 509 g/L at 22 °C and a pH of 9.3. Based on a visual determination the water solubility was found to be > 1.0 kg/L. The difference between the analytical and visual determined water solubility is caused by the purity of the test item and an increased volume after addition of the test item.


Surface tension

According to REACH Annex VII column 2, assessment of surface tension can be waived as no surface activity is expected based on the chemical structure of the substance.


Flash point

After correction for the atmospheric pressure, the flash point of D-Panthenol was determined to be 150.5 °C using the Pensky-Martens flash point apparatus.


Auto flammability

The test material has been determined not to have an auto-ignition temperature below 400°C.



Due to the chemical structure, the substance was considered to have no pyrophoric properties. According to the chemical structure and extended experience in handling and use, the substance was not considered to be flammable in contact with water. The flash point of the substance as a liquid was tested following the Pensky-Martens method and revealed a flash point of 150.5 °C


According to REACH Annex VII column 2, assessment of explosiveness can be waived as the substance contains no chemical groups associated with explosive properties.


Oxidising properties

According to REACH Annex VII, column 2, a study on oxidizing properties needs not to be carried out, if the test item -based on its chemical structure- is unable to react exothermically with flammable substances. This is the case for test item D-Panthenol acc. to the requirements in the UN Recommendations on the Transport of Dangerous Goods (Manual of Tests and Criteria, 4th revised edition, 2003, Appendix 6, "Orange Book"), since the oxygen atoms of this molecule all are bound to carbon atoms. Furthermore the D-Panthenol molecule does not contain chlorine or fluorine atoms. This waiver justification is based on a read across on a Klimisch-1-rated expert statement prepared for DL-Panthenol by Harlan Laboratories Ltd., 2009.


Stability in organic solvents and identity of relevant degradation products

According to REACH Annex IX column 2, assessment of the stability in organic solvents can be waived as the substance is stable in organic solvents from experience in handling and use.


Dissociation constant

A read across approach was performed with the structural similar substance DL-Panthenol. The dissociation constant of DL-Panthenol was determined to 11.6 at 20 °C.


By comparing the test item visually with substances with viscosity in a known range (e.g. honey and syrup) it can be stated that the viscosity of D-Panthenol is higher than approximately 10E6 mPa s. Therefore it was not possible to measure the viscosity experimentally.